@article {Madney00422-2020, author = {Yasmin M. Madney and Nabila Ibrahim Laz and Ahmed A. Elberry and Hoda Rabea and Mohamed E.A. Abdelrahim}, title = {Aerosol delivery aspects within a high flow therapy system in chronic obstructive pulmonary disease patients}, elocation-id = {00422-2020}, year = {2020}, doi = {10.1183/23120541.00422-2020}, publisher = {European Respiratory Society}, abstract = {There is a lack of information about the influence of patient interfaces like facemask or mouthpiece on the effective dose of aerosolized drugs while using high flow therapy in a clinical setting. These interfaces can improve pulmonary drug delivery over nasal cannula but patient preference and comfort should also be considered.The present work was to determine the effect of three different interfaces (nasal cannula, valved face mask, and mouthpiece) when combined with titrated oxygen flow on aerosol delivery in chronic obstructive pulmonary disease (COPD) patients hospitalised due to acute exacerbation.The variations between these interfaces were addressed in terms of change in lung function measurements pre-and post-inhalation, the delivered salbutamol dose, and patient tolerance to each interface.High flow nasal cannula was the most comfortable interface used. However, its pulmonary drug delivery was significantly lower than both the valved face mask and mouthpiece (p\<0.05). Although drug delivery was different with the three tested interfaces, the lung function improvements were similar.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Madney has nothing to disclose.Conflict of interest: Dr. Laz has nothing to disclose.Conflict of interest: Dr. Elberry has nothing to disclose.Conflict of interest: Dr. Rabea has nothing to disclose.Conflict of interest: Dr. Abdelrahim has nothing to disclose.}, URL = {https://openres.ersjournals.com/content/early/2020/10/01/23120541.00422-2020}, eprint = {https://openres.ersjournals.com/content/early/2020/10/01/23120541.00422-2020.full.pdf}, journal = {ERJ Open Research} }