RT Journal Article
SR Electronic
T1 Phenotypic characterisation of early COPD: a prospective case–control study
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00047-2020
DO 10.1183/23120541.00047-2020
VO 6
IS 4
A1 Borja G. Cosío
A1 Sergi Pascual-Guardia
A1 Alicia Borras-Santos
A1 Germán Peces-Barba
A1 Salud Santos
A1 Laura Vigil
A1 Juan José Soler-Cataluña
A1 Cristina Martínez-González
A1 Ciro Casanova
A1 Pedro J. Marcos
A1 Carlos J. Alvarez
A1 José Luis López-Campos
A1 Joaquim Gea
A1 Judith Garcia-Aymerich
A1 Jesús Molina
A1 Miguel Román
A1 Jorge Moises
A1 Viktoria Szabo
A1 Elizabeth A. Reagan
A1 Raúl San José Estépar
A1 George Washko
A1 Alvar Agustí
A1 Rosa Faner
YR 2020
UL http://openres.ersjournals.com/content/6/4/00047-2020.abstract
AB The phenotypic characteristics of chronic obstructive pulmonary disease (COPD) in individuals younger than 50 years of age (early COPD) are not well defined. This prospective, multicentre, case–control study sought to describe these characteristics and compare them with those of smokers (≥10 pack-years) of similar age with normal spirometry (controls).We studied 92 cases (post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.7) and 197 controls. Results were contrasted with participants with similar inclusion criteria recruited into the ECLIPSE and COPDGene cohorts.Cases had moderate airflow limitation (FEV1 71.3±20.8%) but were often symptomatic, used healthcare resources frequently, had air trapping (residual volume 150.6±55.5% ref.), had reduced diffusing capacity (84.2±20.7% ref.) and had frequent evidence of computed tomography (CT) emphysema (61%). Of note, less than half of cases (46%) had been previously diagnosed with COPD. Interestingly, they also often reported a family history of respiratory diseases and had been hospitalised because of respiratory problems before the age of 5 years more frequently than controls (12% versus 3%, p=0.009). By and large, these observations were reproduced when available in the ECLIPSE and COPDGene cohorts.These results show that early COPD is associated with substantial health impact and significant structural and functional abnormalities, albeit it is often not diagnosed (hence, treated). The fact that a sizeable proportion of patients with early COPD report a family history of respiratory diseases and/or early-life events (including hospitalisations before the age of 5 years) renders further support to the possibility of early-life origin of COPD.Early COPD is associated with substantial health impact, and structural and functional abnormalities, albeit it is often not diagnosed and hence, not treated. It is frequently associated with family history of respiratory diseases and early-life events. https://bit.ly/2ZtoRkp