RT Journal Article
SR Electronic
T1 Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00278-2019
DO 10.1183/23120541.00278-2019
VO 6
IS 4
A1 Daniel Morell-Garcia
A1 Núria Toledo-Pons
A1 Pilar Sanchis
A1 Josep Miquel Bauça
A1 José María Sánchez
A1 José Peña-Zarza
A1 Paloma Giménez
A1 Javier Pierola
A1 Mónica de la Peña-Bravo
A1 Alberto Alonso-Fernández
A1 Antònia Barceló
YR 2020
UL http://openres.ersjournals.com/content/6/4/00278-2019.abstract
AB Introduction Red cell distribution width (RDW) is a parameter included in the complete blood count which informs about the size of the circulating red blood cell population and its distribution. In adults, an increase in RDW was shown to be associated both with obstructive sleep apnoea (OSA) and with an increase in cardiovascular mortality. The aim of this study was to determine whether RDW is a potential biomarker for screening children with moderate–severe OSA.Methods An observational study in snoring patients was performed. All patients underwent a sleep study and were classified either as simple snorers (apnoea–hypopnoea index (AHI) <1 event·h−1) or as patients with OSA (mild AHI ≥1 to <5 events·h−1; moderate–severe AHI ≥5 events·h−1). Blood analyses (complete blood count and C-reactive protein) were performed for every individual.Results A total of 175 individuals were recruited. The mean age was 8.3±3.6 years. Correlation studies between RDW and several sleep-related parameters showed negative significant associations with minimum oxygen saturation, and positive significant associations with oxygen desaturation index (≥3% and ≥4%), AHI and the arousal index. A predictive model for paediatric severe OSA (AHI ≥5 events·h−1) was found based on mean corpuscular haemoglobin concentration (MCHC) <34.9 g·dL−1 and RDW >13.1% values, adjusting for body mass index z-score and age (area under the curve 0.657; p=0.004). In addition, differences were found in eosinophil count and C-reactive protein concentrations among the three subgroups.Conclusions In children, RDW stands out as a biomarker associated with the severity of OSA. The use of RDW and MCHC could be a simple but useful tool for the severity prediction of paediatric OSA in snoring patients.Red cell distribution width and mean corpuscular haemoglobin concentration are blood markers associated with the severity of paediatric OSA https://bit.ly/2Asw1xa