PT - JOURNAL ARTICLE AU - Yuji Yamamoto AU - Keisuke Miki AU - Kazuyuki Tsujino AU - Tomoki Kuge AU - Fukuko Okabe AU - Takahiro Kawasaki AU - Takanori Matsuki AU - Hiroyuki Kagawa AU - Mari Miki AU - Hiroshi Kida TI - Oscillometry and Computed Tomography Findings in Patients with Idiopathic Pulmonary Fibrosis AID - 10.1183/23120541.00391-2020 DP - 2020 Jan 01 TA - ERJ Open Research PG - 00391-2020 4099 - http://openres.ersjournals.com/content/early/2020/10/01/23120541.00391-2020.short 4100 - http://openres.ersjournals.com/content/early/2020/10/01/23120541.00391-2020.full AB - Although the utility of oscillometry for predicting disease severity in idiopathic pulmonary fibrosis (IPF) had been researched, little has been reported on the mechanism of why respiratory impedance reflects the disease severity. In addition, traction bronchiectasis has been considered to reduce respiratory resistance and correlate negatively with airflow obstruction, but this hypothesis has not been validated. The present study aimed to investigate the correlations between oscillometric parameters and fibrosis-related lung abnormalities in IPF and to assess the utility of oscillometry as a surrogate marker for traction bronchiectasis and airflow obstruction.Eighty Japanese patients with IPF underwent high-resolution computed tomography (HRCT), spirometry, and oscillometry and were retrospectively investigated. Fibrosis-related HRCT findings were scored regarding airspace consolidation, honeycombing, architectural distortion, traction bronchiectasis, and fibrosis. Correlations between the HRCT scores, spirometric parameters, and oscillometric parameters were analysed.Respiratory reactance correlated positively with all fibrosis-related HRCT scores. Vital capacity and forced vital capacity (FVC) correlated negatively with oscillometric parameters and HRCT scores, reflecting the severity of restrictive ventilatory deficiency. Respiratory resistance was not related to any of the HRCT scores or forced expiration volume in 1 s/FVC. However, forced expiration volume in 1 s/FVC correlated positively with HRCT scores, which showed that airflow obstruction became milder as the disease progressed.In conclusion, respiratory reactance reflects fibrosis and restrictive ventilatory deficiency in IPF. Moreover, respiratory resistance is independent of traction bronchiectasis and airflow obstruction in patients with IPF, which implies that respiratory resistance might reflect different properties of the airways.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Yamamoto has nothing to disclose.Conflict of interest: Dr. Miki has nothing to disclose.Conflict of interest: Dr. Tsujino has nothing to disclose.Conflict of interest: Dr. Kuge has nothing to disclose.Conflict of interest: Dr. Okabe has nothing to disclose.Conflict of interest: Dr. Kawasaki has nothing to disclose.Conflict of interest: Dr. Matsuki has nothing to disclose.Conflict of interest: Dr. Kagawa has nothing to disclose.Conflict of interest: Dr. Miki has nothing to disclose.Conflict of interest: Dr. Kida has nothing to disclose.