TY - JOUR T1 - Newly developed Multiple Breath Washout reference equations from the CHILD Cohort Study: Implications of poorly fitting equations JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00301-2020 SP - 00301-2020 AU - Zihang Lu AU - Ruixue Dai AU - Krzysztof Kowalik AU - Aimee Dubeau AU - Diana L. Lefebvre AU - Susan Balkovec AU - Allan B. Becker AU - Piush J. Mandhane AU - Stuart E. Turvey AU - Wendy Lou AU - Felix Ratjen AU - Theo J. Moraes AU - Malcolm R. Sears AU - Per M. Gustafsson AU - Padmaja Subbarao Y1 - 2020/01/01 UR - http://openres.ersjournals.com/content/early/2020/10/08/23120541.00301-2020.abstract N2 - The multiple-breath washout (MBW) test allows for the measurement of lung volumes, ventilation homogeneity and gas clearance curves during tidal breathing [1]. Lung clearance index (LCI), the most commonly reported parameter from the MBW test, is a marker of ventilation inhomogeneity and is associated with early lung disease. LCI is defined as the cumulative expired volume (CEV) divided by the functional residual capacity (FRC). The currently accepted reference equation for LCI measured using sulfur hexafluoride (SF6) shows a non-linear decrease as age and height increase, with height as an independent predictor from infancy to school-age [2]. In contrast, FRC shows a non-linear increase in FRC as age and height increase with males having higher measured FRC compared to female subjects.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Lu has nothing to disclose.Conflict of interest: Dr. Dai has nothing to disclose.Conflict of interest: Mr. Kowalik has nothing to disclose.Conflict of interest: Dr. Dubeau has nothing to disclose.Conflict of interest: Dr. Lefebvre has nothing to disclose.Conflict of interest: Dr. Balkovec has nothing to disclose.Conflict of interest: Dr. Becker has nothing to disclose.Conflict of interest: Dr. Mandhane has nothing to disclose.Conflict of interest: Dr. Turvey has nothing to disclose.Conflict of interest: Dr. Lou has nothing to disclose.Conflict of interest: Dr. Ratjen reports grants and personal fees from Vertex, personal fees from Novartis, personal fees from Bayer, personal fees from Roche, personal fees from Genetech, outside the submitted work.Conflict of interest: Dr. Moraes has nothing to disclose.Conflict of interest: Dr. Sears has nothing to disclose.Conflict of interest: Per M. GustafssonConflict of interest: Dr. Subbarao has nothing to disclose. ER -