PT - JOURNAL ARTICLE AU - Raquel Pastrello Hirata AU - Daniele Caroline Dala Pola AU - Lorena Paltanin Schneider AU - Mariana Pereira Bertoche AU - Karina Couto Furlanetto AU - Nidia Aparecida Hernandes AU - Arthur Eumann Mesas AU - Fabio Pitta TI - Tossing and turning: association of sleep quantity-quality with physical activity in COPD AID - 10.1183/23120541.00370-2020 DP - 2020 Jan 01 TA - ERJ Open Research PG - 00370-2020 4099 - http://openres.ersjournals.com/content/early/2020/10/08/23120541.00370-2020.short 4100 - http://openres.ersjournals.com/content/early/2020/10/08/23120541.00370-2020.full AB - The association between characteristics of sleep and physical activity in daily life (PADL) was not yet investigated in depth in subjects with chronic obstructive pulmonary disease (COPD). This study evaluated if time spent/day in physical activity (PA) and sedentary behaviour are associated with sleep quantity and quality in this population.Sleep and PADL were objectively assessed by an activity monitor for 7 days and analysed on a minute-by-minute basis. Subjects also underwent spirometry and 6-min walking test (6 MWT).Fifty-five subjects with moderate-to-severe COPD (28 male, 67±8 years) were studied. Subjects with total time in bed/night (TIB) ≥9 h had higher wake after sleep onset than TIB 7–9 h and TIB≤7 h (195 [147–218] versus 117 [75–167] and 106 [84–156] min) and more fragmented sleep than TIB≤7 h (8.2 [6.7–14.3] versus 6.3 [5.6–6.9] sleeping bouts)(p<0.05 for all). Subjects with TIB≥9 h also spent more time/day in sedentary behaviour and less time/day in PA of light and moderate-to-vigorous intensity than those with TIB 7–9 h and ≤7 h. In multiple linear regression, TIB≥9 h was the only significant predictor of physical inactivity (β=−3.3 [−5.1, −1,6], p≤0.0001), accounting for 20% of its variation. Sleep fragmentation was frequent and more pronounced in physically inactive than active patients (7.5 [6.3–9.6] versus 6.4 [5.5–7.3] sleeping bouts; p=0.027).In summary, subjects with COPD with time in bed ≥9 h·night−1 have more fragmented sleep, are more sedentary and less physically active than those with <9 h·night−1, independently of the awake time. Sleep quality is frequently poor and even worse in patients classified as physically inactive.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Hirata has nothing to disclose.Conflict of interest: Dr. Dala Pola has nothing to disclose.Conflict of interest: Dr. Schneider has nothing to disclose.Conflict of interest: Dr. Bertoche has nothing to disclose.Conflict of interest: Dr. Furlanetto has nothing to disclose.Conflict of interest: Dr. Hernandes has nothing to disclose.Conflict of interest: Dr. Mesas has nothing to disclose.Conflict of interest: Dr. Pitta has nothing to disclose.