TY - JOUR T1 - Comparison between traditional and nontraditional add-on devices used with pressurised metered-dose inhalers JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00073-2020 VL - 6 IS - 4 SP - 00073-2020 AU - Mina Nicola AU - Youssef M.A. Soliman AU - Raghda Hussein AU - Haitham Saeed AU - Mohamed Abdelrahim Y1 - 2020/10/01 UR - http://openres.ersjournals.com/content/6/4/00073-2020.abstract N2 - Add-on devices that are attached to metered-dose inhalers (MDIs) were introduced to improve aerosol delivery. The objective of this study was to determine the efficacy of drug delivery from an MDI when attached to different add-on devices at different inhalation volumes.The total emitted dose (TED) of salbutamol was estimated for the MDI alone and the MDI connected to five different add-on devices (Able valved holding chamber, Tips-haler valved holding chamber, Aerochamber plus flow Vu valved holding chamber, Dolphin chamber, and a handmade water bottle spacer), at inhalation flow of 28.3 L·min−1 with flow volume of 1, 2 and 4 L, assuming young child (aged <6 years), old child (>6 years) and adult inhalation volumes, respectively.The TED% ranged between 84.1% and 87.2% at all inhalation volumes from the MDI alone, which was significantly greater than all MDI add-on device combinations (p<0.05). The TED% delivered to MDI sampling apparatus by a homemade water bottle spacer and Dolphin chamber, as non-antistatic add-on devices, ranged between 30.5% and 35.3%. However, washing these non-antistatic add-on devices with a light detergent before use improved their TED to range between 47.6% and 51.2%. Non-antistatic add-on devices had significantly lower TED (p<0.05) than that delivered by most antistatic add-on devices, which ranged from 51.3% to 71.6%.This study suggests that antistatic add-on devices delivered much more aerosol than non-antistatic add-on devices. However, it may be advised to still use a non-antistatic add-on device, for the sake of solving the coordination problem, and wash it with light detergent before use to improve TED.Antistatic add-on devices deliver much more aerosol from MDIs than non-antistatic add-on devices https://bit.ly/3gSE5aR ER -