TY - JOUR T1 - Validation of a composed COVID-19 chest radiography score: the CARE project JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00359-2020 VL - 6 IS - 4 SP - 00359-2020 AU - Chiara Giraudo AU - Annachiara Cavaliere AU - Giulia Fichera AU - Michael Weber AU - Raffaella Motta AU - Michela Pelloso AU - Francesca Tosato AU - Amalia Lupi AU - Fiorella Calabrese AU - Giovanni Carretta AU - Anna Maria Cattelan AU - Giorgio De Conti AU - Vito Cianci AU - Paolo Navalesi AU - Mario Plebani AU - Federico Rea AU - Roberto Vettor AU - Andrea Vianello AU - Roberto Stramare Y1 - 2020/10/01 UR - http://openres.ersjournals.com/content/6/4/00359-2020.abstract N2 - Objectives The aim of this study was to validate a composed coronavirus disease 2019 (COVID-19) chest radiography score (CARE) based on the extension of ground-glass opacity (GG) and consolidations (Co), separately assessed, and to investigate its prognostic performance.Methods COVID-19-positive patients referring to our tertiary centre during the first month of the outbreak in our area and with a known outcome were retrospectively evaluated. Each lung was subdivided into three areas and a three-grade score assessing the extension of GG and Co was used. The CARE was derived from the sum of the subscores. A mixed-model ANOVA with post hoc Bonferroni correction was used to evaluate whether differences related to the referring unit (emergency room, COVID-19 wards and intensive care unit (ICU)) occurred. Logistic regression analyses were used to investigate the impact of CARE, patients’ age and sex on the outcome. To evaluate the prognostic performance of CARE, receiver operating characteristic curves were computed for the entire stay and at admission only.Results A total of 1203 chest radiographs of 175 patients (120 males; mean age 67.81±15.5 years old) were examined. On average, each patient underwent 6.8±10.3 radiographs. Patients in ICU as well as deceased patients showed higher CARE scores (p<0.05, each). Age, Co and CARE significantly influenced the outcome (p<0.05 each). The CARE demonstrated good accuracy (area under the curve (AUC)=0.736) using longitudinal data as well as at admission only (AUC=0.740). A CARE score of 17.5 during hospitalisation showed 75% sensitivity and 69.9% specificity.Conclusions The CARE was demonstrated to be a reliable tool to assess the severity of pulmonary involvement at chest radiography with a good prognostic performance.CARE is a reliable tool with a good prognostic performance to assess the severity of pulmonary involvement due to #COVID19 https://bit.ly/2ERtAWv ER -