RT Journal Article
SR Electronic
T1 Validation of a composed COVID-19 chest radiography score: the CARE project
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00359-2020
DO 10.1183/23120541.00359-2020
VO 6
IS 4
A1 Chiara Giraudo
A1 Annachiara Cavaliere
A1 Giulia Fichera
A1 Michael Weber
A1 Raffaella Motta
A1 Michela Pelloso
A1 Francesca Tosato
A1 Amalia Lupi
A1 Fiorella Calabrese
A1 Giovanni Carretta
A1 Anna Maria Cattelan
A1 Giorgio De Conti
A1 Vito Cianci
A1 Paolo Navalesi
A1 Mario Plebani
A1 Federico Rea
A1 Roberto Vettor
A1 Andrea Vianello
A1 Roberto Stramare
YR 2020
UL http://openres.ersjournals.com/content/6/4/00359-2020.abstract
AB Objectives The aim of this study was to validate a composed coronavirus disease 2019 (COVID-19) chest radiography score (CARE) based on the extension of ground-glass opacity (GG) and consolidations (Co), separately assessed, and to investigate its prognostic performance.Methods COVID-19-positive patients referring to our tertiary centre during the first month of the outbreak in our area and with a known outcome were retrospectively evaluated. Each lung was subdivided into three areas and a three-grade score assessing the extension of GG and Co was used. The CARE was derived from the sum of the subscores. A mixed-model ANOVA with post hoc Bonferroni correction was used to evaluate whether differences related to the referring unit (emergency room, COVID-19 wards and intensive care unit (ICU)) occurred. Logistic regression analyses were used to investigate the impact of CARE, patients’ age and sex on the outcome. To evaluate the prognostic performance of CARE, receiver operating characteristic curves were computed for the entire stay and at admission only.Results A total of 1203 chest radiographs of 175 patients (120 males; mean age 67.81±15.5 years old) were examined. On average, each patient underwent 6.8±10.3 radiographs. Patients in ICU as well as deceased patients showed higher CARE scores (p<0.05, each). Age, Co and CARE significantly influenced the outcome (p<0.05 each). The CARE demonstrated good accuracy (area under the curve (AUC)=0.736) using longitudinal data as well as at admission only (AUC=0.740). A CARE score of 17.5 during hospitalisation showed 75% sensitivity and 69.9% specificity.Conclusions The CARE was demonstrated to be a reliable tool to assess the severity of pulmonary involvement at chest radiography with a good prognostic performance.CARE is a reliable tool with a good prognostic performance to assess the severity of pulmonary involvement due to #COVID19 https://bit.ly/2ERtAWv