RT Journal Article
SR Electronic
T1 Multicentre feasibility of multiple-breath washout in preschool children with cystic fibrosis and other lung diseases
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00408-2020
DO 10.1183/23120541.00408-2020
VO 6
IS 4
A1 Mirjam Stahl
A1 Cornelia Joachim
A1 Ines Kirsch
A1 Tatjana Uselmann
A1 Yin Yu
A1 Nadine Alfeis
A1 Christiane Berger
A1 Rebecca Minso
A1 Isa Rudolf
A1 Cornelia Stolpe
A1 Xenia Bovermann
A1 Lena Liboschik
A1 Alena Steinmetz
A1 Dunja Tennhardt
A1 Friederike Dörfler
A1 Jobst Röhmel
A1 Klaudia Unorji-Frank
A1 Claudia Rückes-Nilges
A1 Bianca von Stoutz
A1 Lutz Naehrlich
A1 Matthias V. Kopp
A1 Anna-Maria Dittrich
A1 Olaf Sommerburg
A1 Marcus A. Mall
YR 2020
UL http://openres.ersjournals.com/content/6/4/00408-2020.abstract
AB Background Multiple-breath washout (MBW)-derived lung clearance index (LCI) detects early cystic fibrosis (CF) lung disease. LCI was used as an end-point in single- and multicentre settings at highly experienced MBW centres in preschool children. However, multicentre feasibility of MBW in children aged 2–6 years, including centres naïve to this technique, has not been determined systematically.Methods Following central training, 91 standardised nitrogen MBW investigations were performed in 74 awake preschool children (15 controls, 46 with CF, and 13 with other lung diseases), mean age 4.6±0.9 years at investigation, using a commercially available device across five centres in Germany (three experienced, two naïve to the performance in awake preschool children) with central data analysis. Each MBW investigation consisted of several measurements.Results Overall success rate of MBW investigations was 82.4% ranging from 70.6% to 94.1% across study sites. The number of measurements per investigation was significantly different between sites ranging from 3.7 to 6.2 (p<0.01), while the mean number of successful measurements per investigation was comparable with 2.1 (range, 1.9 to 2.5; p=0.46). In children with CF, the LCI was increased (median 8.2, range, 6.7–15.5) compared to controls (median 7.3, range 6.5–8.3; p<0.01), and comparable to children with other lung diseases (median 7.9, range, 6.6–13.9; p=0.95).Conclusion This study demonstrates that multicentre MBW in awake preschool children is feasible, even in centres previously naïve, with central coordination to assure standardised training, quality control and supervision. Our results support the use of LCI as multicentre end-point in clinical trials in awake preschoolers with CF.MBW is feasible in awake preschool children with high success rates in a multicentre setting and LCI detects ventilation inhomogeneity in preschool children with CF. This supports LCI as an end-point in early intervention trials in preschool children with CF. https://bit.ly/3lD4wnj