TY - JOUR T1 - Clinical experience with antifibrotics in fibrotic hypersensitivity pneumonitis: a 3-year real-life observational study JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00152-2020 VL - 6 IS - 4 SP - 00152-2020 AU - Vasilios Tzilas AU - Argyris Tzouvelekis AU - Evangelos Bouros AU - Theodoros Karampitsakos AU - Maria Ntassiou AU - Eleni Avdoula AU - Athena Trachalaki AU - Katerina Antoniou AU - Ganesh Raghu AU - Demosthenes Bouros Y1 - 2020/10/01 UR - http://openres.ersjournals.com/content/6/4/00152-2020.abstract N2 - Background Fibrotic hypersensitivity pneumonitis (f-HP) can exhibit a progressive course similar to idiopathic pulmonary fibrosis (IPF). The lack of diagnostic guidelines and randomised controlled trials in this population represent a significant unmet need.Objectives To describe our clinical experience with antifibrotics in patients with f-HP.Material and methods Retrospective study of 30 patients diagnosed with f-HP upon re-evaluation within a multidisciplinary team discussion of 295 consecutive patients (January 2012 to December 2017) who had been diagnosed initially with IPF at outside facilities and were referred to our centres.Results Pirfenidone was initially administered to 14 (46.7%) patients and nintedanib to 16 (53.3%) patients. There were 26 (86.7%) males, with mean±sd age 70.2±8.4 years. The annual rate of decline in forced vital capacity (FVC) % predicted over the 3-year treatment period adjusted for baseline FVC % pred measurement was 4.2% (95% CI 1.9–6.6%, p=0.001) and 7.5% (95% CI 3.3–11.7%; p=0.001) in imputation analysis. The annual rate of decline in diffusing capacity of the lung for carbon monoxide (DLCO) % predicted throughout the 3-year treatment period adjusted for baseline DLCO % pred was 5.7% (95% CI 3.1–8.4%, p<0.001) and 5.8% (95% CI 3.4–8.1%, p<0.001) in imputation analysis. The nature of adverse events was related to the type of antifibrotic agent administered.Conclusion In patients with f-HP receiving antifibrotics there is a statistically significant annual decline in FVC % pred and DLCO % pred over a period of 3 years. Prospective randomised trials exceeding 1 year are warranted to determine the long-term efficacy of antifibrotics.In patients with fibrotic hypersensitivity pneumonitis receiving antifibrotics, there is a statistically significant annual decline in FVC % predicted and DLCO % predicted over a period of 3 years. Prospective randomised trials exceeding 1 year are needed. https://bit.ly/3abhAL9 ER -