TY - JOUR T1 - First analysis of the Severe Paediatric Asthma Collaborative in Europe registry JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00566-2020 VL - 6 IS - 4 SP - 00566-2020 AU - Norrice M. Liu AU - Karin C.L. Carlsen AU - Steve Cunningham AU - Grazia Fenu AU - Louise J. Fleming AU - Monika Gappa AU - Bülent Karadag AU - Fabio Midulla AU - Laura Petrarca AU - Marielle W.H. Pijnenburg AU - Tonje Reier-Nilsen AU - Niels W. Rutjes AU - Franca Rusconi AU - Jonathan Grigg Y1 - 2020/10/01 UR - http://openres.ersjournals.com/content/6/4/00566-2020.abstract N2 - New biologics are being continually developed for paediatric asthma, but it is unclear whether there are sufficient numbers of children in Europe with severe asthma and poor control to recruit to trials needed for registration. To address these questions, the European Respiratory Society funded the Severe Paediatric Asthma Collaborative in Europe (SPACE), a severe asthma registry. We report the first analysis of the SPACE registry, which includes data from 10 paediatric respiratory centres across Europe.Data from 80 children with a clinical diagnosis of severe asthma who were receiving both high-dose inhaled corticosteroid and long-acting β2-agonist were entered into the registry between January 2019 and January 2020. Suboptimal control was defined by either asthma control test, or Global Initiative for Asthma criteria, or ≥2 severe exacerbations in the previous 12 months, or a combination.Overall, 62 out of 80 (77%) children had suboptimal asthma control, of whom 29 were not prescribed a biologic. However, in 24 there was an option for starting a licensed biologic. 33 children with suboptimal control were prescribed a biologic (omalizumab (n=24), or mepolizumab (n=7), or dupilumab (n=2)), and for 29 there was an option to switch to a different biologic.We conclude that the SPACE registry provides data that will support the planning of studies of asthma biologics. Not all children on biologics achieve good asthma control, and there is need for new trial designs addressing biologic switching.Analysis of the Severe Paediatric Asthma Collaborative in Europe (SPACE) registry reveals that asthma control remains suboptimal for some children on biologics and that the registry has the capacity to facilitate trials of new biologics https://bit.ly/3hPA2fu ER -