PT - JOURNAL ARTICLE AU - van ’t Hul, Alex J. AU - Koolen, Eleonore H. AU - Antons, Jeanine C. AU - de Man, Marianne AU - Djamin, Remco S. AU - in ’t Veen, Johannes C.C.M. AU - Simons, Sami O. AU - van den Heuvel, Michel AU - van den Borst, Bram AU - Spruit, Martijn A. TI - Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere AID - 10.1183/23120541.00438-2020 DP - 2020 Oct 01 TA - ERJ Open Research PG - 00438-2020 VI - 6 IP - 4 4099 - https://publications.ersnet.org//content/6/4/00438-2020.short 4100 - https://publications.ersnet.org//content/6/4/00438-2020.full SO - erjor2020 Oct 01; 6 AB - Introduction The present study assessed the prevalence of nine treatable traits (TTs) pinpointing nonpharmacological interventions in patients with COPD upon first referral to a pulmonologist, how these TTs co-occurred and whether and to what extent the TTs increased the odds having a severely impaired health status.Methods Data were collected from a sample of 402 COPD patients. A second sample of 381 patients with COPD was used for validation. Nine TTs were assessed: current smoking status, activity-related dyspnoea, frequent exacerbations <12 months, severe fatigue, depressed mood, poor physical capacity, low physical activity, poor nutritional status and a low level of self-management activation. For each TT the odds ratio (OR) of having a severe health status impairment was calculated. Furthermore, a graphic representation was created, the COPD sTRAITosphere, to visualise TTs prevalence and OR.Results On average 3.9±2.0 TTs per patient were observed. These TTs occurred relatively independently of each other and coexisted in 151 unique combinations. A significant positive correlation was found between the number of TTs and Clinical COPD Questionnaire total score (r=0.58; p<0.001). Patients with severe fatigue (OR: 8.8), severe activity-related dyspnoea (OR: 5.8) or depressed mood (OR: 4.2) had the highest likelihood of having a severely impaired health status. The validation sample corroborated these findings.Conclusions Upon first referral to a pulmonologist, COPD patients show multiple TTs indicating them to several nonpharmacological interventions. These TTs coexist in many different combinations, are relatively independent and increase the likelihood of having a severely impaired health status.Patients with COPD show numerous nonpharmacological treatable traits (TTs) upon referral to a pulmonologist. These TTs coexist in many different combinations, are relatively independent and increase the likelihood of a severely impaired health status. https://bit.ly/355mhpj