TY - JOUR T1 - Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00438-2020 VL - 6 IS - 4 SP - 00438-2020 AU - Alex J. van ’t Hul AU - Eleonore H. Koolen AU - Jeanine C. Antons AU - Marianne de Man AU - Remco S. Djamin AU - Johannes C.C.M. in ’t Veen AU - Sami O. Simons AU - Michel van den Heuvel AU - Bram van den Borst AU - Martijn A. Spruit Y1 - 2020/10/01 UR - http://openres.ersjournals.com/content/6/4/00438-2020.abstract N2 - Introduction The present study assessed the prevalence of nine treatable traits (TTs) pinpointing nonpharmacological interventions in patients with COPD upon first referral to a pulmonologist, how these TTs co-occurred and whether and to what extent the TTs increased the odds having a severely impaired health status.Methods Data were collected from a sample of 402 COPD patients. A second sample of 381 patients with COPD was used for validation. Nine TTs were assessed: current smoking status, activity-related dyspnoea, frequent exacerbations <12 months, severe fatigue, depressed mood, poor physical capacity, low physical activity, poor nutritional status and a low level of self-management activation. For each TT the odds ratio (OR) of having a severe health status impairment was calculated. Furthermore, a graphic representation was created, the COPD sTRAITosphere, to visualise TTs prevalence and OR.Results On average 3.9±2.0 TTs per patient were observed. These TTs occurred relatively independently of each other and coexisted in 151 unique combinations. A significant positive correlation was found between the number of TTs and Clinical COPD Questionnaire total score (r=0.58; p<0.001). Patients with severe fatigue (OR: 8.8), severe activity-related dyspnoea (OR: 5.8) or depressed mood (OR: 4.2) had the highest likelihood of having a severely impaired health status. The validation sample corroborated these findings.Conclusions Upon first referral to a pulmonologist, COPD patients show multiple TTs indicating them to several nonpharmacological interventions. These TTs coexist in many different combinations, are relatively independent and increase the likelihood of having a severely impaired health status.Patients with COPD show numerous nonpharmacological treatable traits (TTs) upon referral to a pulmonologist. These TTs coexist in many different combinations, are relatively independent and increase the likelihood of a severely impaired health status. https://bit.ly/355mhpj ER -