RT Journal Article
SR Electronic
T1 Treatable traits qualifying for nonpharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD sTRAITosphere
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00438-2020
DO 10.1183/23120541.00438-2020
VO 6
IS 4
A1 Alex J. van ’t Hul
A1 Eleonore H. Koolen
A1 Jeanine C. Antons
A1 Marianne de Man
A1 Remco S. Djamin
A1 Johannes C.C.M. in ’t Veen
A1 Sami O. Simons
A1 Michel van den Heuvel
A1 Bram van den Borst
A1 Martijn A. Spruit
YR 2020
UL http://openres.ersjournals.com/content/6/4/00438-2020.abstract
AB Introduction The present study assessed the prevalence of nine treatable traits (TTs) pinpointing nonpharmacological interventions in patients with COPD upon first referral to a pulmonologist, how these TTs co-occurred and whether and to what extent the TTs increased the odds having a severely impaired health status.Methods Data were collected from a sample of 402 COPD patients. A second sample of 381 patients with COPD was used for validation. Nine TTs were assessed: current smoking status, activity-related dyspnoea, frequent exacerbations <12 months, severe fatigue, depressed mood, poor physical capacity, low physical activity, poor nutritional status and a low level of self-management activation. For each TT the odds ratio (OR) of having a severe health status impairment was calculated. Furthermore, a graphic representation was created, the COPD sTRAITosphere, to visualise TTs prevalence and OR.Results On average 3.9±2.0 TTs per patient were observed. These TTs occurred relatively independently of each other and coexisted in 151 unique combinations. A significant positive correlation was found between the number of TTs and Clinical COPD Questionnaire total score (r=0.58; p<0.001). Patients with severe fatigue (OR: 8.8), severe activity-related dyspnoea (OR: 5.8) or depressed mood (OR: 4.2) had the highest likelihood of having a severely impaired health status. The validation sample corroborated these findings.Conclusions Upon first referral to a pulmonologist, COPD patients show multiple TTs indicating them to several nonpharmacological interventions. These TTs coexist in many different combinations, are relatively independent and increase the likelihood of having a severely impaired health status.Patients with COPD show numerous nonpharmacological treatable traits (TTs) upon referral to a pulmonologist. These TTs coexist in many different combinations, are relatively independent and increase the likelihood of a severely impaired health status. https://bit.ly/355mhpj