RT Journal Article SR Electronic T1 Increased nocturnal arterial pulsation frequencies of obstructive sleep apnoea patients is associated with an increased number of lapses in a psychomotor vigilance task JF ERJ Open Research JO erjor FD European Respiratory Society SP 00277-2020 DO 10.1183/23120541.00277-2020 VO 6 IS 4 A1 Samu Kainulainen A1 Brett Duce A1 Henri Korkalainen A1 Akseli Leino A1 Riku Huttunen A1 Laura Kalevo A1 Erna S. Arnardottir A1 Antti Kulkas A1 Sami Myllymaa A1 Juha Töyräs A1 Timo Leppänen YR 2020 UL http://openres.ersjournals.com/content/6/4/00277-2020.abstract AB Objectives Besides hypoxaemia severity, heart rate variability has been linked to cognitive decline in obstructive sleep apnoea (OSA) patients. Thus, our aim was to examine whether the frequency domain features of a nocturnal photoplethysmogram (PPG) can be linked to poor performance in the psychomotor vigilance task (PVT).Methods PPG signals from 567 suspected OSA patients, extracted from Type 1 diagnostic polysomnography, and corresponding results of PVT were retrospectively examined. The frequency content of complete PPGs was determined, and analyses were conducted separately for men (n=327) and women (n=240). Patients were grouped into PVT performance quartiles based on the number of lapses (reaction times ≥500 ms) and within-test variation in reaction times. The best-performing (Q1) and worst-performing (Q4) quartiles were compared due the lack of clinical thresholds in PVT.Results We found that the increase in arterial pulsation frequency (APF) in both men and women was associated with a higher number of lapses. Higher APF was also associated with higher within-test variation in men, but not in women. Median APF (β=0.27, p=0.01), time spent under 90% saturation (β=0.05, p<0.01), female sex (β=1.29, p<0.01), older age (β=0.03, p<0.01) and subjective sleepiness (β=0.07, p<0.01) were significant predictors of belonging to Q4 based on lapses. Only female sex (β=0.75, p<0.01) and depression (β=0.91, p<0.02) were significant predictors of belonging to Q4 based on the within-test variation.Conclusions In conclusion, increased APF in PPG provides a possible polysomnography indicator for deteriorated vigilance especially in male OSA patients. This finding highlights the connection between cardiorespiratory regulation, vigilance and OSA. However, our results indicate substantial sex-dependent differences that warrant further prospective studies.Frequency content analysis of PPG measured in peripheral pulse oximetry offers valuable information on the risk of impaired vigilance. This finding provides new research hypotheses on the connection between sleep, cardiovascular regulation, and vigilance. https://bit.ly/2ZO7ZGc