RT Journal Article SR Electronic T1 Pneumomediastinum and subcutaneous emphysema in COVID-19: barotrauma or lung frailty? JF ERJ Open Research JO erjor FD European Respiratory Society SP 00385-2020 DO 10.1183/23120541.00385-2020 VO 6 IS 4 A1 Daniel H.L. Lemmers A1 Mohammed Abu Hilal A1 Claudio Bnà A1 Chiara Prezioso A1 Erika Cavallo A1 Niccolò Nencini A1 Serena Crisci A1 Federica Fusina A1 Giuseppe Natalini YR 2020 UL http://openres.ersjournals.com/content/6/4/00385-2020.abstract AB Background In mechanically ventilated acute respiratory distress syndrome (ARDS) patients infected with the novel coronavirus disease (COVID-19), we frequently recognised the development of pneumomediastinum and/or subcutaneous emphysema despite employing a protective mechanical ventilation strategy. The purpose of this study was to determine if the incidence of pneumomediastinum/subcutaneous emphysema in COVID-19 patients was higher than in ARDS patients without COVID-19 and if this difference could be attributed to barotrauma or to lung frailty.Methods We identified both a cohort of patients with ARDS and COVID-19 (CoV-ARDS), and a cohort of patients with ARDS from other causes (noCoV-ARDS).Patients with CoV-ARDS were admitted to an intensive care unit (ICU) during the COVID-19 pandemic and had microbiologically confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. NoCoV-ARDS was identified by an ARDS diagnosis in the 5 years before the COVID-19 pandemic period.Results Pneumomediastinum/subcutaneous emphysema occurred in 23 out of 169 (13.6%) patients with CoV-ARDS and in three out of 163 (1.9%) patients with noCoV-ARDS (p<0.001). Mortality was 56.5% in CoV-ARDS patients with pneumomediastinum/subcutaneous emphysema and 50% in patients without pneumomediastinum (p=0.46).CoV-ARDS patients had a high incidence of pneumomediastinum/subcutaneous emphysema despite the use of low tidal volume (5.9±0.8 mL·kg−1 ideal body weight) and low airway pressure (plateau pressure 23±4 cmH2O).Conclusions We observed a seven-fold increase in pneumomediastinum/subcutaneous emphysema in CoV-ARDS. An increased lung frailty in CoV-ARDS could explain this finding more than barotrauma, which, according to its etymology, refers to high transpulmonary pressure.Pneumomediastinum is more frequent in #COVID19 patients with ARDS despite the use of a protective ventilatory approach. Lung frailty, and not barotrauma, appears to be the main cause of this finding. https://bit.ly/36FQe03