TY - JOUR T1 - Contrasting hemodynamic effects of exercise and saline infusion in older adults with pulmonary arterial hypertension JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00183-2020 SP - 00183-2020 AU - Felipe H. Valle AU - Sam Esfandiari AU - Ho-Jun Jang AU - Felipe C. Fuchs AU - Stephen P. Wright AU - John Granton AU - Susanna Mak Y1 - 2020/01/01 UR - http://openres.ersjournals.com/content/early/2020/11/12/23120541.00183-2020.abstract N2 - The contemporary population of patients with pulmonary arterial hypertension (PAH) are older, with high prevalence of cardiovascular risk factors [1], and potentially at risk for left ventricular diastolic dysfunction [2]. Accordingly, the effect of exercise or volume expansion may elicit augmented increases in pulmonary artery wedge pressure (PAWP) [3, 4], in addition to abnormal behavior of pulmonary artery (PA) pressures.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Homem Valle has nothing to disclose.Conflict of interest: Sam EsfandiariConflict of interest: Dr. Jang has nothing to disclose.Conflict of interest: Dr. Fuchs has nothing to disclose.Conflict of interest: Dr. Wright has nothing to disclose.Conflict of interest: Dr. Granton has received support through his foundation from unrestricted grants from Bayer and Jennsen Pharmaceuticals to support research, quality improvement projects and development of educational tools. He has also received payment for participation in steering and adjudication committees of clinical trials sponsored by United Therapeutics and Bellerophon.Conflict of interest: Dr. Mak reports grants from Heart and Stroke Foundation of Canada, grants from Ontario Research Fund, during the conduct of the study; other from Sinai Foundation, outside the submitted work. ER -