TY - JOUR T1 - Inflammatory myofibroblastic tumor of the central airways: treatment and molecular analysis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00151-2020 SP - 00151-2020 AU - A. Iyer AU - T. Radonic AU - L.C. Heukamp AU - E. Thunnissen AU - J.M.A. Daniels Y1 - 2020/01/01 UR - http://openres.ersjournals.com/content/early/2020/11/19/23120541.00151-2020.abstract N2 - Inflammatory myofibroblastic tumors (IMT) are a rare cause of endobronchial masses in adults. Surgery has been the main stay of treatment of endobronchial IMTs, based on the potential for recurrence. Interventional pulmonology has emerged as a minimally invasive and lung function preserving modality in management of airway obstruction due to tumors. We present a series of 3 adult patients with IMT treated endo-bronchially with a short discussion on its potential role. We also discuss how molecular analysis of IMTs for mutations in genes such as ALK and ROS1 might provide insights into clinical behavior and potential targetable therapy in advanced, unresectable and metastatic cases.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Iyer has nothing to disclose.Conflict of interest: Dr. Radonic has nothing to disclose.Conflict of interest: Dr. Heukamp has nothing to disclose.Conflict of interest: Dr. Thunnissen has nothing to disclose.Conflict of interest: Dr. Daniels has nothing to disclose. ER -