RT Journal Article
SR Electronic
T1 Use of the ReCIVA device in breath sampling of patients with acute breathlessness: a feasibility study
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00119-2020
DO 10.1183/23120541.00119-2020
VO 6
IS 4
A1 Karl A. Holden
A1 Wadah Ibrahim
A1 Dahlia Salman
A1 Rebecca Cordell
A1 Teresa McNally
A1 Bharti Patel
A1 Rachael Phillips
A1 Caroline Beardsmore
A1 Michael Wilde
A1 Luke Bryant
A1 Amisha Singapuri
A1 Paul Monks
A1 Chris Brightling
A1 Neil Greening
A1 Paul Thomas
A1 Salman Siddiqui
A1 Erol A. Gaillard
YR 2020
UL http://openres.ersjournals.com/content/6/4/00119-2020.abstract
AB Introduction Investigating acute multifactorial undifferentiated breathlessness and understanding the driving inflammatory processes can be technically challenging in both adults and children. Being able to validate noninvasive methods such as breath analysis would be a huge clinical advance. The ReCIVA® device allows breath samples to be collected directly onto sorbent tubes at the bedside for analysis of exhaled volatile organic compounds (eVOCs). We aimed to assess the feasibility of using this device in acutely breathless patients.Methods Adults hospitalised with acute breathlessness and children aged 5–16 years with acute asthma or chronic stable asthma, as well as healthy adult and child volunteers, were recruited. Breath samples were collected onto sorbent tubes using the ReCIVA® device and sent for analysis by means of two-dimensional gas chromatography-mass spectrometry (GCxGC-MS). The NASA Task Load Index (NASA-TLX) was used to assess the perceived task workload of undertaking sampling from the patient's perspective.Results Data were available for 65 adults and 61 children recruited. In total, 98.4% of adults and 75.4% of children were able to provide the full target breath sample using the ReCIVA® device. NASA-TLX measurements were available in the adult population with mean values of 3.37 for effort, 2.34 for frustration, 3.8 for mental demand, 2.8 for performance, 3.9 for physical demand and 2.8 for temporal demand.Discussion This feasibility study demonstrates it is possible and acceptable to collect breath samples from both adults and children at the bedside for breathomics analysis using the ReCIVA® device.It is feasible to collect breath samples for breath analysis at the bedside using the ReCIVA device in acutely breathless adults and children https://bit.ly/2ZTonWo