PT - JOURNAL ARTICLE AU - Matthias Ebner AU - Niklas Guddat AU - Karsten Keller AU - Marie Christine Merten AU - Markus H. Lerchbaumer AU - Gerd Hasenfuß AU - Stavros V. Konstantinides AU - Mareike Lankeit TI - High-sensitivity troponin I for risk stratification in normotensive pulmonary embolism AID - 10.1183/23120541.00625-2020 DP - 2020 Oct 01 TA - ERJ Open Research PG - 00625-2020 VI - 6 IP - 4 4099 - http://openres.ersjournals.com/content/6/4/00625-2020.short 4100 - http://openres.ersjournals.com/content/6/4/00625-2020.full SO - erjor2020 Oct 01; 6 AB - While numerous studies have confirmed the prognostic role of high-sensitivity troponin T (hsTnT) in pulmonary embolism (PE), high-sensitivity troponin I (hsTnI) is inappropriately studied. This study aimed to investigate the prognostic relevance of hsTnI in normotensive PE, establish the optimal cut-off value for risk stratification and to compare the prognostic performances of hsTnI and hsTnT.Based on data from 459 consecutive PE patients enrolled in a single-centre registry, receiver operating characteristic analysis was used to identify an optimal hsTnI cut-off value for prediction of in-hospital adverse outcomes (PE-related death, cardiopulmonary resuscitation or vasopressor treatment) and all-cause mortality.Patients who suffered an in-hospital adverse outcome (4.8%) had higher hsTnI concentrations compared with those with a favourable clinical course (57 (interquartile range (IQR) 22–197) versus 15 (IQR 10–86) pg·mL−1, p=0.03). A hsTnI cut-off value of 16 ng·mL−1 provided optimal prognostic performance and predicted in-hospital adverse outcomes (OR 6.5, 95% CI 1.9–22.4) and all-cause mortality (OR 3.7, 95% CI 1.0–13.3). Between female and male patients, no relevant differences in hsTnI concentrations (17 (IQR 10–97) versus 17 (IQR 10–92) pg·mL−1, p=0.79) or optimised cut-off values were observed. Risk stratification according to the 2019 European Society of Cardiology algorithm revealed no differences if calculated based on either hsTnI or hsTnT (p=0.68).Our findings confirm the prognostic role of hsTnI in normotensive PE. HsTnI concentrations >16 pg·mL−1 predicted in-hospital adverse outcome and all-cause mortality; sex-specific cut-off values do not seem necessary. Importantly, our results suggest that hsTnI and hsTnT can be used interchangeably for risk stratification.The study confirms the prognostic relevance of high-sensitivity troponin I in normotensive pulmonary embolism. A cut-off value of 16 pg·mL−1 can be used for risk stratification in male and female patients; sex-specific adjustments do not appear necessary. https://bit.ly/3lCECip