PT - JOURNAL ARTICLE AU - Grace Y. Lam AU - Jodi Goodwin AU - Pearce G. Wilcox AU - Bradley S. Quon TI - Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes AID - 10.1183/23120541.00475-2020 DP - 2021 Jan 01 TA - ERJ Open Research PG - 00475-2020 VI - 7 IP - 1 4099 - http://openres.ersjournals.com/content/7/1/00475-2020.short 4100 - http://openres.ersjournals.com/content/7/1/00475-2020.full SO - erjor2021 Jan 01; 7 AB - Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how oestrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone-related therapeutic interventions is also discussed.A disparity in survival has been noted between men and women with cystic fibrosis where female sex hormones may facilitate lung disease progression. There is strong evidence that implicates oestrogen in numerous aspects of CF airway pathophysiology. https://bit.ly/34ef4Cv