PT  - JOURNAL ARTICLE
AU  - Gabriel García
AU  - Miguel Bergna
AU  - Juan C. Vásquez
AU  - Maria C. Cano Salas
AU  - José L. Miguel
AU  - Carlos Celis Preciado
AU  - Agustin Acuña Izcaray
AU  - Manuel Barros Monge
AU  - Natalia García Batista
AU  - Ignacio Zabert
AU  - José L. Mayorga
AU  - Renato Casanova Mendoza
AU  - Martha Gutierrez
AU  - Maria F. Montero Arias
AU  - Luzcenelia Urtecho Perez
AU  - Miguel Antúnez
AU  - Victoria Williams Derby
AU  - Alejandra Villatoro Azméquita
AU  - Luis Motiño
AU  - M. Alenita De Oliveira
AU  - Diana Rey Sanchez
AU  - Marisol Arroyo
AU  - Mario Rodriguez
TI  - Severe asthma: adding new evidence – Latin American Thoracic Society
AID  - 10.1183/23120541.00318-2020
DP  - 2021 Jan 01
TA  - ERJ Open Research
PG  - 00318-2020
VI  - 7
IP  - 1
4099  - http://openres.ersjournals.com/content/7/1/00318-2020.short
4100  - http://openres.ersjournals.com/content/7/1/00318-2020.full
SO  - erjor2021 Jan 01; 7
AB  - This document constitutes a summary of the clinical practice guidelines (CPGs) prepared at the initiative of the Latin American Thoracic Society (ALAT). Due to new evidence in the treatment of severe asthma, it was agreed to select six clinical questions, and the corresponding recommendations are provided herein. After considering the quality of the evidence, the balance between desirable and undesirable impacts and the feasibility and acceptance of procedures, the following recommendations were established. 1) We do not recommend the use of an inhaled corticosteroid (ICS) plus formoterol as rescue medication in the treatment of severe asthma. 2) We suggest performing many more high-quality randomised studies to evaluate the efficacy and safety of tiotropium in patients with severe asthma. 3) Omalizumab is recommended in patients with severe uncontrolled allergic asthma with serum IgE levels above 30 IU. 4) Anti-interleukin (IL)-5 drugs are recommended in patients with severe uncontrolled eosinophilic asthma (cut-off values above 150 cells·µL−1 for mepolizumab and above 400 cells·µL−1 for reslizumab). 5) Benralizumab is recommended in adult patients with severe uncontrolled eosinophilic asthma (cut-off values above 300 cells·µL−1). 6) Dupilumab is recommended in adult patients with severe uncontrolled allergic and eosinophilic asthma and in adult patients with severe corticosteroid-dependent asthma.Severe #asthma: evidence @ALATorax https://bit.ly/34jYhg2