TY - JOUR T1 - Higher interleukin-6 levels and changes in transforming growth factor-β are associated with lung impairment in pulmonary tuberculosis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00390-2020 VL - 7 IS - 1 SP - 00390-2020 AU - Akshay N. Gupte AU - Sriram Selvaraju AU - Sanjay Gaikwad AU - Vidya Mave AU - Pavan Kumar AU - Subash Babu AU - Bruno B. Andrade AU - William Checkley AU - Robert Bollinger AU - Amita Gupta A2 - , Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/7/1/00390-2020.abstract N2 - Pulmonary tuberculosis (PTB) is associated with granuloma formation, necrosis and cavitation in lung tissue. Lung injury in PTB can persist despite microbiological cure and is associated with COPD independent of smoking exposure [1]. Furthermore, pulmonary sequelae of PTB are an under-recognised cause of respiratory disability and excess mortality [2].Higher levels of IL-6 and slow-to-resolve TGF-β are associated with lung impairment in treated tuberculosis. These results have important implications for clinical trials of immunomodulatory therapies to prevent tuberculosis-associated lung disease. https://bit.ly/2FQEtszWe thank Artur Queiroz (FIOCRUZ and MONSTER Initiative, Salvador, Brazil) for designing the figures in this manuscript. ER -