TY - JOUR T1 - The six million dollar man JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00341-2020 VL - 7 IS - 1 SP - 00341-2020 AU - Mathilde Volpato AU - Stefan Nowak AU - Jean Luc Bourrain AU - Pascal Demoly AU - Engi Ahmed AU - Arnaud Bourdin AU - Jeremy Charriot Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/7/1/00341-2020.abstract N2 - We report here the observation of a 60-year-old male jeweller who was suffering from severe asthma. Asthma onset was reported by age 30. The patient also reported comorbid severe chronic rhinosinusitis with nasal polyposis since adolescence. Aspirin and nonsteroidal anti-inflammatory drug intolerance was considered to worsen the patient's asthma symptoms, since he had experienced one episode of emergency room attendance shortly after aspirin ingestion. Episodes of generalised chronic urticaria led to genuine anaphylactic reactions that were treated with epinephrine twice in the past, but fortunately without the need for orotracheal intubation. No trigger for these episodes could be identified despite appropriate provocation tests.In this case report, relapse of urticaria after a switch from oma- to mepolizumab successfully led to combination of biologics https://bit.ly/2GykNtI ER -