TY - JOUR T1 - Analysis of pathological changes of the epithelium in the COVID-19 patient airways JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00690-2020 SP - 00690-2020 AU - Wenguang Yin AU - Weitao Cao AU - Guangde Zhou AU - Lifei Wang AU - Jing Sun AU - Airu Zhu AU - Zhongfang Wang AU - Yumin Zhou AU - Xiaoqing Liu AU - Yimin Li AU - Nanshang Zhong AU - Jincun Zhao AU - Lei Liu AU - Pixin Ran Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/01/14/23120541.00690-2020.abstract N2 - The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 70 million infections and approximately 1.6 million deaths worldwide [1]. However, the pathological changes in the COVID-19 airways remain unclear due to limited accessibility of autopsy or biopsy.The severe COVID-19 patient airways plugged by MUC5A-containing mucus exhibit hyperplasia of goblet cells and hypoplasia of multiciliated cells and club cells as well as significant reduced CC16 and MUC5B levels and increased IL-13 levels.We thank Ruiting Sun for imaging assistance. ER -