TY - JOUR T1 - A new KIF5B-ERBB4 gene fusion in a lung adenocarcinoma patient JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00582-2020 SP - 00582-2020 AU - Edouard Guenzi AU - Johan Pluvy AU - Alice Guyard AU - Marina Nguenang AU - Khedidja Rebah AU - Zoubida Benrahmoune AU - Jérome Lamoril AU - Aurelie Cazes AU - Valérie Gounant AU - Solenn Brosseau AU - Catherine Boileau AU - Gérard Zalcman AU - Nathalie Theou-Anton Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/01/21/23120541.00582-2020.abstract N2 - In cancer patients, few ERBB4 fusions have been reported in the literature with different gene partners (IKZF, B4GALT5, EZR [1–3]) allowing dimerisation and constitutive activation of ERBB4 tyrosine kinase domain. Here we report a new fusion of ERBB4 with the coiled-coil domain encoded by KIF5B gene, a universal partner in lung cancer gene fusions, in a patient with a stage IV lung adenocarcinoma.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. GUENZI has nothing to disclose.Conflict of interest: Dr. Pluvy reports personal fees from BMS, non-financial support from MSD, personal fees from Astra-Zeneca, outside the submitted work.Conflict of interest: Dr. Guyard has nothing to disclose.Conflict of interest: Dr. REBAH has nothing to disclose.Conflict of interest: BENRAHMOUNE ZOUBIDA has nothing to disclose.Conflict of interest: Dr. Lamoril has nothing to disclose.Conflict of interest: Dr. Cazes reports personal fees from AstraZeneca, personal fees from Boehringer-Ingelheim, personal fees from Roche, personal fees from MSD, outside the submitted work.Conflict of interest: Dr. Gounant reports personal fees from astra zeneca, personal fees from BMS, personal fees from chugai, personal fees from msd, personal fees from roche, outside the submitted work.Conflict of interest: Dr. Brosseau has nothing to disclose.Conflict of interest: Dr. Boileau has nothing to disclose.Conflict of interest: Dr. ZALCMAN reports non-financial support from ROCHE, personal fees and non-financial support from ASTRA-ZENECA, grants, personal fees and non-financial support from BMS, non-financial support from MSD, non-financial support from Pfizer, non-financial support from Takeda, non-financial support from Abbvie, non-financial support from Da Volterra, outside the submitted work.Conflict of interest: Dr. Théou-Anton reports grants and personal fees from astra zeneca, and Takeda, outside the submitted work.Conflict of interest: Dr. Nguenang has nothing to disclose. ER -