PT - JOURNAL ARTICLE AU - Cvejic, Lydia AU - Guiney, Nadine AU - Nicholson, Tiffany AU - Lau, Kenneth K. AU - Finlay, Paul AU - Hamza, Kais AU - Osadnik, Christian AU - Leong, Paul AU - MacDonald, Martin AU - King, Paul T. AU - Bardin, Philip G. TI - Aspiration and severe exacerbations in COPD: a prospective study AID - 10.1183/23120541.00735-2020 DP - 2021 Jan 01 TA - ERJ Open Research PG - 00735-2020 VI - 7 IP - 1 4099 - http://openres.ersjournals.com/content/7/1/00735-2020.short 4100 - http://openres.ersjournals.com/content/7/1/00735-2020.full SO - erjor2021 Jan 01; 7 AB - Rationale Swallow may be compromised in COPD leading to aspiration and adverse respiratory consequences. However, prevalence and consequences of detectable aspiration in stable COPD are not known.Objectives We tested the hypothesis that a significant number of patients with stable COPD will have detectable aspiration during swallow (prandial aspiration) and that they would experience more frequent severe acute exacerbations of COPD (AECOPD) over the subsequent 12 months.Methods Patients (n=151) with verified and stable COPD of all severities were recruited at a tertiary care hospital. Videofluoroscopy was conducted to evaluate aspiration using Rosenbek's scale for penetration–aspiration during 100-mL cup drinking. AECOPD was documented as moderate (antibiotics and/or corticosteroid treatment) or severe (emergency department admission or hospitalisation) over the ensuing 12 months.Measurements and main results Aspiration was observed in 30 out of 151 patients (19.9%, 18 males, 12 females; mean age 72.4 years). Patients with aspiration had more overall AECOPD events (3.03 versus 2 per patient; p=0.022) and severe AECOPD episodes (0.87 versus 0.39; p=0.032). Severe AECOPD occurred in more patients with aspiration (50% of patients versus 18.2%; OR 4.5, CI 1.9–10.5; p=0.001) and with silent aspiration (36.7% versus 18.2%; OR 2.6, CI 1.1–6.2; p=0.045). Aspiration was related to a shorter exacerbation-free period during the 12-month follow-up period (p=0.038).Conclusions Prandial aspiration is detectable in a subset of patients with COPD and was predictive of subsequent severe AECOPD. Studies to examine if the association is causal are essential to direct strategies aimed at prevention of aspiration and AECOPD.This study demonstrates that prandial aspiration occurs in ∼20% of patients with stable COPD and portends severe COPD exacerbations over the next 12 months https://bit.ly/2Tx5btj