PT  - JOURNAL ARTICLE
AU  - Berta Saez-Gimenez
AU  - Miriam Barrecheguren
AU  - Maria Antònia Ramon
AU  - Alba Gomez-Garrido
AU  - Carlos Bravo
AU  - Víctor Monforte
AU  - Manuel López-Meseguer
AU  - Cristina Berastegui
AU  - Eva Revilla
AU  - Christian Romero
AU  - Rosalía Laporta
AU  - Sonia Fernández-Rozas
AU  - Javier Redel-Montero
AU  - Amparo Solé
AU  - Mercedes de la Torre
AU  - Luis Puente
AU  - Antonio Roman
AU  - Susana Gómez-Ollés
AU  - Iñigo Ojanguren
TI  - Near-normal aerobic capacity in long-term survivors after lung transplantation
AID  - 10.1183/23120541.00381-2020
DP  - 2021 Jan 01
TA  - ERJ Open Research
PG  - 00381-2020
VI  - 7
IP  - 1
4099  - http://openres.ersjournals.com/content/7/1/00381-2020.short
4100  - http://openres.ersjournals.com/content/7/1/00381-2020.full
SO  - erjor2021 Jan 01; 7
AB  - The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives.Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity.Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET).Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders.Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD.This is a multicentre study reporting, for the first time, near-normal peak V′O2 values during cardiopulmonary exercise testing and normal exercise capacity in long-term lung transplant recipients without CLAD https://bit.ly/35ftce3