RT Journal Article
SR Electronic
T1 Near-normal aerobic capacity in long-term survivors after lung transplantation
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00381-2020
DO 10.1183/23120541.00381-2020
VO 7
IS 1
A1 Berta Saez-Gimenez
A1 Miriam Barrecheguren
A1 Maria Antònia Ramon
A1 Alba Gomez-Garrido
A1 Carlos Bravo
A1 Víctor Monforte
A1 Manuel López-Meseguer
A1 Cristina Berastegui
A1 Eva Revilla
A1 Christian Romero
A1 Rosalía Laporta
A1 Sonia Fernández-Rozas
A1 Javier Redel-Montero
A1 Amparo Solé
A1 Mercedes de la Torre
A1 Luis Puente
A1 Antonio Roman
A1 Susana Gómez-Ollés
A1 Iñigo Ojanguren
YR 2021
UL http://openres.ersjournals.com/content/7/1/00381-2020.abstract
AB The clinical course of lung transplantation (LT) is diverse: some patients present chronic lung allograft dysfunction (CLAD) and progressive decline in pulmonary function, but others maintain normal spirometric values and active lives.Objectives The aim of this study was to elucidate whether long-term LT survivors with normal spirometry achieve normal exercise capacity, and to identify predictive factors of exercise capacity.Methods This was a cross-sectional multicentre study, where bilateral LT recipients who survived at least 10 years after LT, with normal spirometry, no diagnosis of CLAD and modified Medical Research Council dyspnoea degree ≤2 underwent cardiopulmonary exercise testing (CPET).Results 28 LT recipients were included with a mean±sd age of 48.7±13.6 years. Oxygen uptake (V′O2) had a mean±sd value of 21.49±6.68 mL·kg−1·min−1 (75.24±15.6%) and the anaerobic threshold was reached at 48.6±10.1% of the V′O2max predicted. The mean±sd heart rate reserve at peak exercise was 17.56±13.6%. The oxygen pulse increased during exercise and was within normal values at 90.5±19.4%. The respiratory exchange ratio exceeded 1.19 at maximum exercise. The median (25–75th percentile) EuroQol-5D score was 1 (0.95–1), indicating a good quality of life. The median (25–75th percentile) International Physical Activity Questionnaire score was 5497 (4007–9832) MET-min·week−1 with 89% of patients reporting more than 1500 MET-min·week−1. In the multivariate regression models, age, sex and diffusing capacity of the lung for carbon monoxide remained significantly associated with V′O2max (mL·kg−1·min−1); haemoglobin and forced expiratory volume in 1 s were significantly associated with maximum work rate (watts), after adjusting for confounders.Conclusion We report for the first time near-normal peak V′O2 values during CPET and normal exercise capacity in long-term LT recipients without CLAD.This is a multicentre study reporting, for the first time, near-normal peak V′O2 values during cardiopulmonary exercise testing and normal exercise capacity in long-term lung transplant recipients without CLAD https://bit.ly/35ftce3