TY - JOUR T1 - Conditional expanding post-exposure prophylaxis: a potential new tool for tuberculosis control JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00723-2020 VL - 7 IS - 1 SP - 00723-2020 AU - Henan Xin AU - Qi Jin AU - Lei Gao Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/7/1/00723-2020.abstract N2 - The latest consolidated guideline on tuberculosis (TB) preventive treatment, released by World Health Organization (WHO) in 2020, strongly recommended that children aged <5 years who are household contacts of people with bacteriologically confirmed pulmonary TB and who are found not to have active TB should be recommended for TB preventive treatment even if TB infection testing is unavailable [1]. That means preventative treatment should be administrated to the children aged <5 years once exposure has occurred. The concept of such post-exposure prophylaxis (PEP) has been successfully practised for HIV prevention among at-risk individuals with occupational exposure or non-occupational exposure [2]. For TB, PEP is still a new concept, here we raise a proposal to explore whether PEP could be scaled up to the other high-risk populations as a potential tool to accelerate the achievement of the END TB global goal [3]. The development of a new strategy requires systematic research and sufficient evidence; hence, we are only undertaking some preliminary discussion here.For individuals with high risk of exposure and thereafter developing and transmitting active tuberculosis, conditional post-exposure prophylaxis might be a potential tool for tuberculosis control https://bit.ly/39qHHh4 ER -