%0 Journal Article %A Jonathan Pham %A Matthew Conron %A Gavin Wright %A Paul Mitchell %A David Ball %A Jennifer Philip %A Margaret Brand %A John Zalcberg %A Rob G Stirling %T Excess mortality and undertreatment in elderly lung cancer patients: treatment nihilism in the modern era? %D 2021 %R 10.1183/23120541.00393-2020 %J ERJ Open Research %P 00393-2020 %X Background Treatment of elderly patients with lung cancer is significantly hindered by concerns about treatment tolerability, toxicity and limited clinical trial data in the elderly – potentially giving rise to treatment nihilism amongst clinicians. This study aims to describe survival in elderly patients with lung cancer and explore potential causes for excess mortality.Methods Patients diagnosed with lung cancer in the Victorian Lung Cancer Registry between 2011–2018 were analysed (n=3481). Patients were age-categorised and compared using Cox-regression modelling to determine mortality risk, after adjusting for confounding. Probability of being offered cancer treatments was also determined, further stratified by disease stage.Results The eldest patients (≥80 years old) had significantly shorter median survival compared to younger age groups (<60: 2.0 years; 60–69: 1.5 years; 70–79: 1.6 years; ≥80: 1.0 years; p<0.001). Amongst those diagnosed with stage 1 or 2 lung cancer, there was no significant difference in adjusted-mortality between age groups. However, in those diagnosed with stage 3 or 4 disease, the eldest patients had an increased adjusted-mortality risk of 28% compared to patients younger than 60 years (p=0.005), associated with markedly reduced probability of cancer treatment, after controlling for sex, performance status, comorbidities and histology type (OR 0.24, compared to <60 years old strata, p<0.001).Conclusion Compared to younger patients, older patients with advanced-stage lung cancer have a disproportionately higher risk of mortality and lower likelihood of receiving cancer treatments, even when performance status and comorbidity are equivalent. These healthcare inequities could be indicative of widespread treatment nihilism towards elderly patients.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Pham has nothing to disclose.Conflict of interest: Matthew Conron has nothing to disclose.Conflict of interest: Dr. Wright has nothing to disclose.Conflict of interest: Dr. Mitchell has nothing to disclose.Conflict of interest: D. Ball reports lectures fees from AstraZeneca outside the submitted work.Conflict of interest: Dr. Philip has nothing to disclose.Conflict of interest: Ms Brand has nothing to disclose.Conflict of interest: J. Zalcberg reports support for data collection from AstraZeneca, BMS, MSD and Abbvie outside the submitted work.Conflict of interest: Dr. Stirling has nothing to disclose. %U https://openres.ersjournals.com/content/erjor/early/2021/02/18/23120541.00393-2020.full.pdf