TY - JOUR T1 - Contributions of asthma, rhinitis, and IgE to exhaled nitric oxide in adolescents JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00945-2020 SP - 00945-2020 AU - Bess M. Flashner AU - Sheryl L. Rifas-Shiman AU - Emily Oken AU - Carlos A. Camargo, Jr. AU - Thomas A. E. Platts-Mills AU - Lisa Workman AU - Augusto A. Litonjua AU - Diane R. Gold AU - Mary B. Rice Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/03/11/23120541.00945-2020.abstract N2 - Fractional exhaled nitric oxide (FeNO) is an indicator of allergic airway inflammation. However, it is unknown how asthma, allergic rhinitis (AR) and allergic sensitisation relate to FeNO, particularly among adolescents and in overlapping conditions. We sought to determine the associations between asthma, AR, and aeroallergen IgE and FeNO in adolescents.We measured FeNO among 929 adolescents (11–16 years) in Project Viva, an unselected prebirth cohort in Massachusetts. We defined asthma as ever asthma physician diagnosis plus wheezing in the past year or taking asthma medications in the past month; AR as a physician diagnosis of hay fever or AR; and aeroallergen IgE as any IgE>0.35 IU·mL−1 among 592 participants who provided blood samples. We examined associations of asthma, AR, and IgE with percent difference in FeNO in linear regression models adjusted for sex, race/ethnicity, age and height; maternal education and smoking during pregnancy; and household/neighborhood demographics.Asthma (14%) was associated with 97% higher FeNO (95%CI 70, 128%), AR (21%) with 45% higher FeNO (95%CI 28, 65%), and aeroallergen IgE (58%) with 102% higher FeNO (95%CI 80, 126%) compared to those without each condition, respectively. In the absence of asthma or AR, aeroallergen IgE was associated with 75% higher FeNO (95%CI 52, 101), while asthma and AR were not associated with FeNO in the absence of IgE.The link between asthma and AR with FeNO is limited to those with IgE-mediated phenotypes. FeNO may be elevated in those with allergic sensitisation alone, even in the absence of asthma or AR.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Flashner has nothing to disclose.Conflict of interest: Dr. Rifas-Shiman reports grants from NIH, during the conduct of the study.Conflict of interest: Dr. Oken reports grants from the US National Institutes of Health, during the conduct of the study.Conflict of interest: Dr. Camargo has nothing to disclose.Conflict of interest: Dr. Platts-Mills has nothing to disclose.Conflict of interest: Dr. Workman has nothing to disclose.Conflict of interest: Dr. Litonjua has nothing to disclose.Conflict of interest: Dr. Gold reports grants from NIH, during the conduct of the study.Conflict of interest: Dr. Rice reports grants from NIH during the conduct of the study. ER -