TY - JOUR T1 - Respiratory care in myotubular myopathy JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00641-2020 VL - 7 IS - 1 SP - 00641-2020 AU - Hui-leng Tan AU - Elaine Chan Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/7/1/00641-2020.abstract N2 - X-linked myotubular myopathy is a neuromuscular condition caused by pathogenic variants in the MTM1 gene, which encodes for myotubularin, a phosphatidylinositol 3-phosphate phosphatase. Affected individuals typically require intensive medical intervention to survive, though there are some milder phenotypes. To date, respiratory management has been primarily supportive, optimising clearance of airway secretions, providing ventilatory support and prevention/early intervention of respiratory infections. Encouragingly, there has been significant progress in the development of novel therapeutic strategies such as gene therapy, enzyme replacement therapy and drugs that modulate downstream pathways. In this review, we discuss the common respiratory issues using four illustrative real-life cases, and summarise recent translational research, which offers hope to many patients and their families.A proactive approach is the cornerstone to respiratory care in MTM patients: optimising clearance of airway secretions, preventing/early treatment of respiratory infections and providing ventilatory support to those who need it https://bit.ly/2LYFzW2 ER -