PT  - JOURNAL ARTICLE
AU  - Bashar N. Alzghoul
AU  - Farah N. Amer
AU  - Diana Barb
AU  - Ayoub Innabi
AU  - Mamoun T. Mardini
AU  - Chen Bai
AU  - Bara Alzghoul
AU  - Tamara Al-Hakim
AU  - Noopur Singh
AU  - Mindy Buchanan
AU  - Leslie Serchuck
AU  - Diana Gomez Manjarres
AU  - Whitney W. Woodmansee
AU  - Lisa A. Maier
AU  - Divya C. Patel
TI  - Prevalence and characteristics of self-reported hypothyroidism and its association with nonorgan-specific manifestations in US sarcoidosis patients: a nationwide registry study
AID  - 10.1183/23120541.00754-2020
DP  - 2021 Jan 01
TA  - ERJ Open Research
PG  - 00754-2020
VI  - 7
IP  - 1
4099  - http://openres.ersjournals.com/content/7/1/00754-2020.short
4100  - http://openres.ersjournals.com/content/7/1/00754-2020.full
SO  - erjor2021 Jan 01; 7
AB  - Little is known about the prevalence, clinical characteristics and impact of hypothyroidism in patients with sarcoidosis. We aimed to determine the prevalence and clinical features of hypothyroidism and its relation to organ involvement and other clinical manifestations in patients with sarcoidosis.We conducted a national registry-based study investigating 3835 respondents to the Sarcoidosis Advanced Registry for Cures Questionnaire between June 2014 and August 2019. This registry is based on a self-reported, web-based questionnaire that provides data related to demographics, diagnostics, sarcoidosis manifestations and treatment. We compared sarcoidosis patients with and without self-reported hypothyroidism. We used multivariable logistic regression and adjusted for potential confounders to determine the association of hypothyroidism with nonorgan-specific manifestations.14% of the sarcoidosis patients self-reported hypothyroidism and were generally middle-aged white women. Hypothyroid patients had more comorbid conditions and were more likely to have multiorgan sarcoidosis involvement, especially with cutaneous, ocular, joints, liver and lacrimal gland involvement. Self-reported hypothyroidism was associated with depression (adjusted odds ratio (aOR) 1.3, 95% CI 1.01–1.6), antidepressant use (aOR 1.3, 95% CI 1.1–1.7), obesity (aOR 1.7, 95% CI 1.4–2.1), sleep apnoea (aOR 1.7, 95% CI 1.3–2.2), chronic fatigue syndrome (aOR 1.5, 95% CI 1.2–2) and was borderline associated with fibromyalgia (aOR 1.3, 95% CI 1–1.8). Physical impairment was more common in patients with hypothyroidism.Hypothyroidism is a frequent comorbidity in sarcoidosis patients that might be a potentially reversible contributor to fatigue, depression and physical impairment in this population. We recommend considering routine screening for hypothyroidism in sarcoidosis patients especially in those with multiorgan sarcoidosis, fatigue and depression.Hypothyroidism is a frequent comorbidity in sarcoidosis patients, is often associated with sarcoidosis multiorgan involvement, and might be a potentially reversible contributor to fatigue, depression and physical impairment in this population https://bit.ly/2XGdjKg