TY - JOUR T1 - Confocal laser endomicroscopy to guide sampling of a pure ground-glass opacity JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00910-2020 VL - 7 IS - 2 SP - 00910-2020 AU - Thibault Viatgé AU - Thomas Villeneuve AU - Dominique D'Aure AU - Julien Mazières AU - Gavin Plat AU - Christophe Hermant AU - Nicolas Guibert Y1 - 2021/04/01 UR - http://openres.ersjournals.com/content/7/2/00910-2020.abstract N2 - We read with great interest the article “Needle-based confocal laser endomicroscopy [CLE] for real-time diagnosing and staging of lung cancer” by Wijmans et al. [1], recently published in the European Respiratory Journal, demonstrating the feasibility and safety of realtime lung cancer detection by endosonography-guided CLE. The authors elegantly describe three CLE characteristics for lung cancer: dark, enlarged pleomorphic cells; dark clumps; and directional streaming. The accuracy of CLE for detecting malignancy was 90% in tumours and 89% in metastatic lymph nodes.Confocal laser endomicroscopy imaging of lepidic adenocarcinomas is feasible. This technique should be further evaluated as a realtime guiding tool during virtual electromagnetic navigation bronchoscopy for ground-glass opacities https://bit.ly/3uzTcMU ER -