RT Journal Article
SR Electronic
T1 Dyspnoea and symptom burden in mild–moderate COPD: the Canadian Cohort Obstructive Lung Disease Study
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00960-2020
DO 10.1183/23120541.00960-2020
VO 7
IS 2
A1 Mathew Cherian
A1 Dennis Jensen
A1 Wan C. Tan
A1 Sara Mursleen
A1 Emma C. Goodall
A1 Gilbert A. Nadeau
A1 Amnah M. Awan
A1 Darcy D. Marciniuk
A1 Brandie L. Walker
A1 Shawn D. Aaron
A1 Denis E. O'Donnell
A1 Kenneth R. Chapman
A1 François Maltais
A1 Paul Hernandez
A1 Don D. Sin
A1 Andrea Benedetti
A1 Jean Bourbeau
YR 2021
UL http://openres.ersjournals.com/content/7/2/00960-2020.abstract
AB Studies assessing dyspnoea and health-related quality of life (HRQoL) in chronic obstructive pulmonary disease (COPD) have focussed on patients in clinical settings, not the general population.The aim of this analysis was to compare the prevalence and severity of dyspnoea and impaired HRQoL in individuals with and without COPD from the general population, focussing on mild–moderate COPD.Analysis of the 3-year Canadian Cohort Obstructive Lung Disease (CanCOLD) study included four subgroups: mild COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1); moderate COPD (GOLD 2); non-COPD smokers; and non-COPD never-smokers. The primary outcome was dyspnoea (Medical Research Council (MRC) scale), and the secondary outcome was HRQoL (COPD Assessment Test (CAT) score; Saint George's Respiratory Questionnaire (SGRQ) score). Subgroups were analysed by sex, physician-diagnosed COPD status and exacerbations.1443 participants (mild COPD (n=397); moderate COPD (n=262(; smokers (n=449) and never-smokers (n=335)) were studied. People with mild COPD were more likely to report more severe dyspnoea (MRC 2 versus 1) than those without COPD (OR (95% CI) 1.42 (1.05–1.91)), and non-COPD never-smokers (OR (95%CI) 1.64 (1.07–2.52)). Among people with mild COPD, more severe dyspnoea was reported in women versus men (MRC2 versus 1; OR (95% CI) 3.70 (2.23–6.14)); people with, versus without, physician-diagnosed COPD (MRC2 versus 1; OR (95% CI) 3.27 (1.71–6.23)), and people with versus without recent exacerbations (MRC2 versus 1; ≥2 versus 0 exacerbations: OR (95% CI) 3.62 (1.02–12.86); MRC ≥3 versus 1; 1 versus 0 exacerbation: OR (95% CI): 9.24 (2.01–42.42)). Similar between-group differences were obtained for CAT and SGRQ scores.Careful assessment of dyspnoea and HRQoL could help identify individuals for earlier diagnosis and treatment.Individuals from a population-based study with mild COPD are more symptomatic than non-COPD peers. Worse dyspnoea and quality of life was reported by people with mild COPD who are female, or have a physician diagnosis of COPD or recent exacerbations. https://bit.ly/2XE2B6S