RT Journal Article
SR Electronic
T1 BronchUK: protocol for an observational cohort study and biobank in bronchiectasis
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00775-2020
DO 10.1183/23120541.00775-2020
VO 7
IS 2
A1 Anthony De Soyza
A1 Philip Mawson
A1 Adam T. Hill
A1 Stuart Elborn
A1 Judy M. Bradley
A1 Charles S. Haworth
A1 R. Andres Floto
A1 Robert Wilson
A1 Michael R. Loebinger
A1 Mary Carroll
A1 Megan Crichton
A1 James D. Chalmers
A1 Anita Sullivan
A1 Jeremy Brown
A1 John R. Hurst
A1 Jamie Duckers
A1 Martin Kelly
A1 John Steer
A1 Tim Gatheral
A1 Paul P. Walker
A1 Craig Winstanley
A1 Alistair McGuire
A1 David Denning
A1 Richard McNally
YR 2021
UL http://openres.ersjournals.com/content/7/2/00775-2020.abstract
AB Bronchiectasis has been a largely overlooked disease area in respiratory medicine. This is reflected by a shortage of large-scale studies and lack of approved therapies, in turn leading to a variation of treatment across centres. BronchUK (Bronchiectasis Observational Cohort and Biobank UK) is a multicentre, prospective, observational cohort study working collaboratively with the European Multicentre Bronchiectasis Audit and Research Collaboration project. The inclusion criteria for patients entering the study are a clinical history consistent with bronchiectasis and computed tomography demonstrating bronchiectasis. Main exclusion criteria are 1) patients unable to provide informed consent, 2) bronchiectasis due to known cystic fibrosis or where bronchiectasis is not the main or co-dominant respiratory disease, 3) age <18 years, and 4) prior lung transplantation for bronchiectasis. The study is aligned to standard UK National Health Service (NHS) practice with an aim to recruit a minimum of 1500 patients from across at least nine secondary care centres. Patient data collected at baseline includes demographics, aetiology testing, comorbidities, lung function, radiology, treatments, microbiology and quality of life. Patients are followed up annually for a maximum of 5 years and, where able, blood and/or sputa samples are collected and stored in a central biobank. BronchUK aims to collect robust longitudinal data that can be used for analysis into current NHS practice and patient outcomes, and to become an integral resource to better inform future interventional studies in bronchiectasis.BronchUK is a multicentre, observational cohort study and biobank collecting longitudinal patient data to be used for analysis into current NHS practice and patient outcomes, and to better inform the design of future interventional studies https://bit.ly/3svngZc