PT - JOURNAL ARTICLE AU - Harriet Mpairwe AU - Richard Stephen Mpango AU - Wilber Sembajjwe AU - Emily L. Webb AU - Alison M. Elliott AU - Neil Pearce AU - Eugene Kinyanda TI - Anxiety disorders and asthma among adolescents in Uganda: role of early-life exposures AID - 10.1183/23120541.00749-2020 DP - 2021 Apr 01 TA - ERJ Open Research PG - 00749-2020 VI - 7 IP - 2 4099 - http://openres.ersjournals.com/content/7/2/00749-2020.short 4100 - http://openres.ersjournals.com/content/7/2/00749-2020.full SO - erjor2021 Apr 01; 7 AB - The reasons for the positive association between anxiety disorders and asthma are unknown. We investigated the possible role of shared exposures in early life.We conducted a case–control study among adolescents (age 12–17 years) with and without asthma in urban Uganda, as part of a larger asthma case–control study. Anxiety disorders were diagnosed by psychiatric clinical officers. We focused on generalised anxiety disorder (GAD), panic disorder and social anxiety disorder. Asthma was doctor-diagnosed by study clinicians. We used questionnaires to collect data on early-life exposures. The data were analysed using multiple logistic regression.We enrolled 162 adolescents; 73 of them had asthma. Adolescents with asthma were more likely to have any of the three anxiety disorders studied (46.6%) than adolescents without asthma (21.4%) (adjusted OR (aOR) 2.68, 95% CI 1.30–5.53). The association was strong for GAD (aOR 4.49, 95% CI 1.48–13.56) and panic disorder (aOR 5.43, 95% CI 2.11–14.02), but not for social anxiety disorder. The early-life risk factors associated with anxiety disorders among adolescents were similar to asthma risk factors previously published, including urban residence at birth (aOR 3.42, 95% CI 1.29–9.09) and during most of the first 5 years of life (aOR 2.87, 95% CI 1.07–7.66), father's tertiary education (aOR 2.09, 95% CI 1.00–4.37), and adolescent's history of other allergy-related diseases (aOR 4.64, 95% CI 1.66–13.00).We confirm a positive association between anxiety disorders and asthma among adolescents in urban Uganda. The early-life risk factors associated with anxiety disorders among adolescents were similar to those for asthma in the same age group, suggesting shared underlying environmental exposures.In this study in Uganda, adolescents with anxiety disorders were more likely to have asthma. Both conditions had similar risk factors in early life, including urban residence and higher parental education, suggesting shared underlying exposures. https://bit.ly/3rCtcPa