TY - JOUR T1 - Nocturnal oxygen saturation parameters as predictive factors for DM2 among OSA patients JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.sleepandbreathing-2021.66 VL - 7 IS - suppl 7 SP - 66 AU - A Gabryelska AU - J Chrzanowski AU - M Sochal AU - P Kaczmarski AU - P BiaƂasiewicz Y1 - 2021/04/16 UR - http://openres.ersjournals.com/content/7/suppl_7/66.abstract N2 - Background and aims: Obstructive sleep apnea is a recognized independent risk factor for metabolic disorders, type 2 diabetes mellites (DM2) in particular. Therefore, the study aimed to assess the influence of nocturnal oxygen saturation parameters on the onset of DM2 among OSA patients.Methods: The study consisted of 549 participants, who underwent polysomnography (PSG) examination. Based onapnea hypopnea index (AHI) 465patients were diagnosed with OSA. One hounded and seven individuals had comorbid type 2 diabetes mellites (DM2). Cox regression models were used to assess theeffect ofoxygen saturation parameterson theonset of DM2.Classification and regression trees (CART) analysis wasused to assessthe onset of the DM2 in the study group in context of oxygen saturation variables. Funded by the Polish Ministry of Science and Higher Education grant no. 0067/DIA/2018/47.Results: One-way Cox regression showed higher risk of earlier DM2 for increased values of BMI (p<0.001, 95%CI 1.083-1.153, HR=1.117), AHI (p=0.003, 95%CI 1.004-1.017,HR=1.011), decreased basal O2 (p=0.006, 95%CI 0.886 - 0.9809, HR=0.933) and O2 nadir (p=0.009, 95%CI 0.972-0.996, HR=0.984) value, while lowered mean O2 desaturation has not shown statistical significance. In the CART analysis following cut-off points 92.2%, 81.7%, 87.1% were determined for basal O2, O2 nadir and mean O2 desaturation respectively with first 2 parameters being statistically significant.Conclusions: Higher SpO2 nadir and basal SpO2 are associated with the later onset of DM2 in OSA patients. Basal O2 is independent from AHI, BMI and age is a predictor of DM2 among OSA patients.FootnotesCite this article as ERJ Open Research 2021; 7: Suppl. 7, 66.This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -