PT - JOURNAL ARTICLE AU - A Sabil AU - M Blanchard AU - W Trzepizur AU - F Goupil AU - N Meslier AU - A Paris AU - T Pigeanne AU - P Priou AU - M Le Vaillant AU - F Gagnadoux TI - Prevalence, characteristics, and treatment outcomes of positional obstructive sleep apnea in the pays de la Loire Sleep Cohort AID - 10.1183/23120541.sleepandbreathing-2021.31 DP - 2021 Apr 16 TA - ERJ Open Research PG - 31 VI - 7 IP - suppl 7 4099 - http://openres.ersjournals.com/content/7/suppl_7/31.short 4100 - http://openres.ersjournals.com/content/7/suppl_7/31.full SO - erjor2021 Apr 16; 7 AB - Study objectives: To evaluate, in a large multicenter clinical cohort of obstructive sleep apnea (OSA) patients, the prevalence and factors independently associated with predominant positional OSA (POSA, [IAHD/IAHND≥2]) and exclusive POSA (e-POSA, [OSA + IAHND<5]). The secondary objective was to assess the outcome of CPAP treatment for these patients.Methods: This retrospective study included 6,437 typical mild‐to‐severe OSA patients. Patients with POSA and e-POSA were compared to those without POSA (NPOSA) for clinical and polygraphic characteristics. In a subgroup of patients (n=3,000) included in a CPAP therapy follow-up analysis, we assessed whether POSA and e-POSA phenotypes were associated with treatment outcomes at 6 months.Results: POSA and e-POSA had a prevalence of 53.5% and 20.1% respectively and were independently associated with time in supine position (longer), gender (male), age (younger), AHI (lower) and BMI (lower). After adjusting for confounding factors, patients with POSA or e-POSA had a significantly lower probability of adhering to CPAP therapy (≥4h/day) at 6 months. In addition, compared to NPOSA patients, these patients had a higher risk of discontinuing CPAP treatment.Conclusions: The prevalence and independent predictors of POSA and e-POSA were determined in this large clinical population. POSA and e-POSA patients have lower CPAP adherence and this choice of treatment may not be optimal. Thus, an alternative therapy should be considered for these patients.FootnotesCite this article as ERJ Open Research 2021; 7: Suppl. 7, 31.This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).