TY - JOUR T1 - Non-invasive ventilation (NIV) with auto-EPAP in elderly patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.sleepandbreathing-2021.65 VL - 7 IS - suppl 7 SP - 65 AU - B Han AU - Z Zhang AU - L Yue AU - J Zhang AU - X Hu AU - D Zhang AU - L Liu AU - S Zang AU - S Xing Y1 - 2021/04/16 UR - http://openres.ersjournals.com/content/7/suppl_7/65.abstract N2 - Objective: To investigate the impact of different EPAP levels in NIV on elderly OSAHS patients.Methods: A comparative study, all patients were diagnosed with OSAHS, a total of 48 elderly patients were included (age: (71±8.4 yrs,BMI:28.3±7.4kg/m2). Depending on the level of EPAP , all subjects were randomly divided (1:1:1) into three groups: Narrow scale-EPAP group (EPAP min=8cmH2O, EPAPmax=10cmH2O), Wide scale-EPAP group (EPAP min=4cmH2O,EPAPmax=16 cmH2O) and fixed EPAP group (EPAP=8cmH2O), all patients underwent NIV, AVAPS-AE mode in both Narrow scale-EPAP group and Wide scale- EPAP group; AVAPS mode in the fixed EPAP group.Results: There were significant differences in leakage among the “Fixed-scale EPAP” and “Wide-scale EPAP group” (18.2±4.4L/min VS.15.4±2.5 L/min, p=0.037), lower occurrence of intra-abdominal hypertension in Wide-scale EPAP group than in Fixed-scale EPAP group(p<0.05).There were no differences in lowest oxygen saturation(LSaO2) and improvement of Epworth Sleepiness Scale(ESS) and AHI among three groups. Compared with wide scale-EPAP group, higher occurrence of patient-ventilator asynchronization in fixed EPAP group: but there was no statistical differences(43.8% vs. 25.0%,X2=1.247,p=0.264).Conclusions: For elderly OSAHS patients, a varying range of EPAP maybe more likely to improve their comfort during NIV ,rather than a fixed EPAP level. But, there were no significant differences in changes in improvement of LSaO2 ,ESS and AHI, our results need further study.FootnotesCite this article as ERJ Open Research 2021; 7: Suppl. 7, 65.This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -