PT  - JOURNAL ARTICLE
AU  - N M Geneidy
AU  - A F Elbehairy
AU  - M S El Hoshy
AU  - M K El Feky
AU  - D El-Sanhoury
AU  - N H Abd Elwahab
TI  - Increased arterial stiffness in patients with obstructive sleep apnea: clinical implication
AID  - 10.1183/23120541.sleepandbreathing-2021.62
DP  - 2021 Apr 16
TA  - ERJ Open Research
PG  - 62
VI  - 7
IP  - suppl 7
4099  - http://openres.ersjournals.com/content/7/suppl_7/62.short
4100  - http://openres.ersjournals.com/content/7/suppl_7/62.full
SO  - erjor2021 Apr 16; 7
AB  - Aim: To study the effect of increased arterial stiffness in OSA on patient-centered outcomes.Methods: We assessed peripheral arterial stiffness (pulse wave velocity (PWV) and augmentation index (AIx)) in 14 OSA patients and 10 controls (CTRL); matched for age, body mass index (BMI) and FEV1. Resting echocardiogram, spirometry and incremental exercise test were done.Results: Compared with CTRL, patients [age:50±11 yrs, BMI:31±3 kg/m2, FEV1:84±14 %predicted, apnoea hypopnea index (AHI): 43±19/hour; mean±SD] had greater PWV (7.3±1.2 vs. 5.9±0.9 m/sec) and AIx (29±13 vs. 15±5 %), p<0.05. Peak work rate (WR) and oxygen uptake were lower and iso-WR dyspnea was greater in patients vs. CTRL during exercise (p<0.05). Among arterial stiffness & echocardiographic measurements and exercise measures of ventilatory efficiency, only PWV correlated with OSA severity indices: AHI (r=0.57, p=0.03), O2 desaturation index (r=0.53, p=0.04), and minimal overnight O2 saturation (r=-0.75, p<0.01), Figure. Furthermore, PWV correlated with peak WR (r=-0.55, p=0.01) and the slope of dyspnea/WR during exercise (r=0.71, p<0.001) in patients.Conclusion: Patients with OSA had evidence of increased arterial stiffness compared with controls; that correlated with indices of disease severity. Moreover, increased arterial stiffness could partially explain patient-centered outcomes such as increased exertional dyspnea and reduced exercise capacity.FootnotesCite this article as ERJ Open Research 2021; 7: Suppl. 7, 62.This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).