TY - JOUR T1 - Ventilatory phenotypes of sleep apnoea subtypes at a chronic delay following a first ischemic stroke: a cross-sectional analysis of a prospective clinical-based cohort study JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.sleepandbreathing-2021.22 VL - 7 IS - suppl 7 SP - 22 AU - S Baillieul AU - S Alexandre AU - O Detante AU - M Destors AU - R Guzun AU - D Majorie AU - S Bailly AU - R Tamisier AU - J Pépin Y1 - 2021/04/16 UR - http://openres.ersjournals.com/content/7/suppl_7/22.abstract N2 - Introduction: Up to 40% of patients present an apnoea-hypopnoea index (AHI)>20/h at a chronic delay post-stroke. The ventilatory phenotype of sleep apnoea (SA) after stroke is not yet precisely described.Aim and objectives: To determine the prevalence and ventilatory phenotypic traits of obstructive (OSA), central (CSA), and coexistent OSA/CSA sleep apnoea at a chronic delay following a first-ever ischemic stroke.Methods: Cross-sectional analysis of a prospective, monocentric cohort conducted in a university hospital. 380 consecutive unselected first-ever stroke or transient ischemic attack (TIA) patients were screened over a 3-year period. Full-night polysomnography (PSG), arterial blood gases (ABG), and hypercapnic ventilatory response (HCVR) using a rebreathing test method were performed at a median [Q1; Q3] delay of 134.5 [97; 227.3] days following stroke onset.Results: PSG, ABG, and HCVR were obtained in 112 patients with a first-ever ischemic stroke. Using an AHI cut-off of 15 events.hour-1 of sleep, 56 (50.0%) patients were classified as having moderate to severe SA. Among them, 31 (55.4%) and 25 (44.6%) presented OSA and Coexistent OSA/CSA or CSA respectively. CO2 chemosensitivity significantly differed according to the presence or the type of SA. Coexistent OSA/CSA and CSA patients exhibited higher CO2 chemosensitivity levels compared to No SA patients (p=0.043). No difference was observed regarding ABG parameters.Conclusions: A higher CO2 chemosensitivity in Coexistent OSA/CSA and CSA patients following stroke may dedicate these patients to specific care and ventilatory support.FootnotesCite this article as ERJ Open Research 2021; 7: Suppl. 7, 22.This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -