TY - JOUR T1 - Rs2070600 SNP regulates <em>AGER</em> splicing and the sputum levels of the COPD biomarker sRAGE JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00947-2020 SP - 00947-2020 AU - Alen Faiz AU - Senani N.H. Rathnayake AU - Nick H. T. ten Hacken AU - Victor Guryev AU - Maarten van den Berge AU - Simon D. Pouwels Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/04/29/23120541.00947-2020.abstract N2 - Several studies found that the systemic soluble receptor for advanced glycation end-products (sRAGE) levels are decreased in chronic obstructive pulmonary disease (COPD) patients and strongly correlate with lung function decline, emphysema and disease progression [1–6]. Therefore, the COPD Biomarker Qualification Consortium and the Biomarker Development Center recently put sRAGE forward as the most promising biomarker for COPD [7]. sRAGE is anti-inflammatory decoy receptor for the pro-inflammatory innate immune receptor RAGE, which is transcribed from the AGER gene. It was shown that one particular single nucleotide polymorphism (SNP) decreases the circulating levels of sRAGE in COPD patients [3].FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Faiz has nothing to disclose.Conflict of interest: Dr. Rathnayake has nothing to disclose.Conflict of interest: Dr. ten Hacken has nothing to disclose.Conflict of interest: Dr. Guryev has nothing to disclose.Conflict of interest: Dr. van den Berge has nothing to disclose.Conflict of interest: Dr. Pouwels has nothing to disclose. ER -