PT  - JOURNAL ARTICLE
AU  - Driendl, Sarah
AU  - Arzt, Michael
AU  - Zimmermann, Claudia S.
AU  - Jung, Bettina
AU  - Pukrop, Tobias
AU  - Böger, Carsten A.
AU  - Haferkamp, Sebastian
AU  - Zeman, Florian
AU  - Heid, Iris M.
AU  - Stadler, Stefan
TI  - Sleep apnoea and incident malignancy in type 2 diabetes
AID  - 10.1183/23120541.00036-2021
DP  - 2021 Apr 01
TA  - ERJ Open Research
PG  - 00036-2021
VI  - 7
IP  - 2
4099  - https://publications.ersnet.org//content/7/2/00036-2021.short
4100  - https://publications.ersnet.org//content/7/2/00036-2021.full
SO  - erjor2021 Apr 01; 7
AB  - Background Sleep apnoea and type 2 diabetes (T2D) have been linked to malignancy. The aim of the present study was to evaluate the association between sleep apnoea and incidence of malignancy in patients with T2D.Methods The DIACORE (DIAbetes COhoRtE) study is a prospective, population-based cohort study in T2D patients. In the sleep disordered breathing substudy, the apnoea–hypopnoea index (AHI), oxygen desaturation index (ODI) and percentage of night-time spent with a peripheral oxygen saturation of <90% (tsat90%) were assessed using a two-channel ambulatory monitoring device. Malignancy diagnoses were gathered using self-reported medical history data validated by medical records. Hazard ratios (HRs) for incident malignancy were derived by Cox regression adjusting for sex, age, body mass index, smoking status, alcohol intake, socioeconomic status and HbA1c.Results Of 1239 patients with T2D (mean age 67 years, 41% female, mean body mass index 30.9 kg·m−2), 79 (6.4%) were first-time diagnosed with a malignancy within a median follow-up period of 2.7 years (interquartile range 2.2–4.5 years). AHI, ODI and tsat90% were not associated with incident malignancy. In subgroup analysis, females showed increased cancer risk per AHI unit (adjusted HR 1.03 per AHI unit, 95% CI 1.00–1.06; p=0.028) and severe sleep apnoea (defined as AHI ≥30 events·h−1; adjusted HR 4.19, 95% CI 1.39–12.77; p=0.012). This was not seen in males, and a significant interaction was observed (interaction terms p=0.048 and p=0.033, respectively).Conclusion Sleep apnoea was not associated with incident malignancy in T2D patients. However, stratified analysis revealed a significant association between sleep apnoea and incident malignancy in females, but not in males.In patients with type 2 diabetes, sleep apnoea is not associated with the incidence of malignancy. However, stratified analysis shows that sleep apnoea is associated with incident malignancy in females, but not in males. https://bit.ly/37RAK8V