TY - JOUR T1 - Non-dipping nocturnal blood pressure correlates with obstructive sleep apnoea severity in normotensive subjects and may reverse with therapy JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00338-2021 SP - 00338-2021 AU - Sophie J. Crinion AU - Jana Kleinerova AU - Brian Kent AU - Geraldine Nolan AU - Cormac T. Taylor AU - Silke Ryan AU - Walter T. McNicholas Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/06/17/23120541.00338-2021.abstract N2 - Obstructive sleep apnoea (OSA) is highly prevalent in the general population with an estimated global prevalence of close to one billion affected [1]. Hypertension is present in up to 50% of patients with OSA, which is about double the prevalence of hypertension in general population studies [2]. A non-dipping nocturnal BP profile (<10% day-to-night systolic blood pressure difference) is especially likely in OSA patients [3–6], even in the absence of significant hypertension. The likelihood of non-dipping BP correlates with OSA severity in population studies [7] and cardiovascular events are more frequent in OSA patients with a non-dipping BP profile than those with a normal dipping pattern, even in the absence of diagnosed hypertension [8]. Despite the extensive publications on the relationships between OSA and hypertension and responses to therapy, there are few data on the relationship between OSA and 24-hour BP patterns in OSA patients who are normotensive on 24-hour ambulatory BP monitoring (ABPM) and free of any cardiovascular disease or other chronic disorders.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Crinion has nothing to disclose.Conflict of interest: Dr. Kleinerova has nothing to disclose.Conflict of interest: Dr. Kent has nothing to disclose.Conflict of interest: Ms. Nolan has nothing to disclose.Conflict of interest: Prof. Taylor has nothing to disclose.Conflict of interest: Dr. Ryan has nothing to disclose.Conflict of interest: Prof. McNicholas has nothing to disclose. ER -