PT  - JOURNAL ARTICLE
AU  - Nobuyasu Awano
AU  - Taisuke Jo
AU  - Hideo Yasunaga
AU  - Minoru Inomata
AU  - Naoyuki Kuse
AU  - Mari Tone
AU  - Kojiro Morita
AU  - Hiroki Matsui
AU  - Kiyohide Fushimi
AU  - Takahide Nagase
AU  - Takehiro Izumo
TI  - Body mass index and in-hospital mortality in patients with acute exacerbation of idiopathic pulmonary fibrosis
AID  - 10.1183/23120541.00037-2021
DP  - 2021 Apr 01
TA  - ERJ Open Research
PG  - 00037-2021
VI  - 7
IP  - 2
4099  - http://openres.ersjournals.com/content/7/2/00037-2021.short
4100  - http://openres.ersjournals.com/content/7/2/00037-2021.full
SO  - erjor2021 Apr 01; 7
AB  - Background Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic fibrosis, and acute exacerbation of IPF (AE-IPF) is the leading cause of death in patients with IPF. Data on the association between the body mass index (BMI) and prognosis of AE-IPF are lacking. This study was performed to evaluate the association between BMI and in-hospital mortality in patients who developed AE-IPF using a national inpatient database.Methods Using the Japanese Diagnosis Procedure Combination database, we retrospectively collected data of inpatients with AE-IPF from 1 July, 2010 to 31 March, 2018. We performed a multivariable logistic regression analysis to evaluate the association between all-cause in-hospital mortality and BMI, categorised as underweight (<18.5 kg·m−2), low-normal weight (18.5–22.9 kg·m−2), high-normal weight (23.0–24.9 kg·m−2), overweight (25.0–29.9 kg·m−2) and obese (≥30.0 kg·m−2).Results In total, 14 783 patients were eligible for this study. The in-hospital mortality rate was 59.0%, 55.0%, 53.8%, 54.8% and 46.0% in the underweight, low-normal weight, high-normal weight, overweight and obese groups, respectively. Underweight patients had a significantly higher mortality rate (OR 1.25, 95% CI 1.10–1.42) and obese patients had a significantly lower mortality rate (OR 0.71, 95% CI 0.54–0.94) than low-normal weight patients.Conclusion Among patients with AE-IPF, the underweight group had higher mortality and the obese group had lower mortality.Among patients with acute exacerbation of idiopathic pulmonary fibrosis, underweight patients have higher mortality and obese patients lower mortality https://bit.ly/3eoVMOR