RT Journal Article
SR Electronic
T1 Body mass index and in-hospital mortality in patients with acute exacerbation of idiopathic pulmonary fibrosis
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00037-2021
DO 10.1183/23120541.00037-2021
VO 7
IS 2
A1 Awano, Nobuyasu
A1 Jo, Taisuke
A1 Yasunaga, Hideo
A1 Inomata, Minoru
A1 Kuse, Naoyuki
A1 Tone, Mari
A1 Morita, Kojiro
A1 Matsui, Hiroki
A1 Fushimi, Kiyohide
A1 Nagase, Takahide
A1 Izumo, Takehiro
YR 2021
UL http://openres.ersjournals.com/content/7/2/00037-2021.abstract
AB Background Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic fibrosis, and acute exacerbation of IPF (AE-IPF) is the leading cause of death in patients with IPF. Data on the association between the body mass index (BMI) and prognosis of AE-IPF are lacking. This study was performed to evaluate the association between BMI and in-hospital mortality in patients who developed AE-IPF using a national inpatient database.Methods Using the Japanese Diagnosis Procedure Combination database, we retrospectively collected data of inpatients with AE-IPF from 1 July, 2010 to 31 March, 2018. We performed a multivariable logistic regression analysis to evaluate the association between all-cause in-hospital mortality and BMI, categorised as underweight (<18.5 kg·m−2), low-normal weight (18.5–22.9 kg·m−2), high-normal weight (23.0–24.9 kg·m−2), overweight (25.0–29.9 kg·m−2) and obese (≥30.0 kg·m−2).Results In total, 14 783 patients were eligible for this study. The in-hospital mortality rate was 59.0%, 55.0%, 53.8%, 54.8% and 46.0% in the underweight, low-normal weight, high-normal weight, overweight and obese groups, respectively. Underweight patients had a significantly higher mortality rate (OR 1.25, 95% CI 1.10–1.42) and obese patients had a significantly lower mortality rate (OR 0.71, 95% CI 0.54–0.94) than low-normal weight patients.Conclusion Among patients with AE-IPF, the underweight group had higher mortality and the obese group had lower mortality.Among patients with acute exacerbation of idiopathic pulmonary fibrosis, underweight patients have higher mortality and obese patients lower mortality https://bit.ly/3eoVMOR