TY - JOUR T1 - Defining end-systolic pressure for single beat estimation of right ventricle-pulmonary artery coupling: simple… but not really JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00219-2021 SP - 00219-2021 AU - Inderjit Singh AU - Hannah Oakland AU - Ahmed Elassal AU - Paul M. Heerdt Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/07/08/23120541.00219-2021.abstract N2 - Functional adaptation of the right ventricle (RV) to its afterload plays an important prognostic role in pulmonary hypertension (PH) [1]. The preferred “multibeat” (MB) method for assessing RV - pulmonary vascular interaction involves the measurement of end-systolic elastance (Ees), the slope of the end-systolic pressure (ESP) to end-systolic volume over sequential heart beats with varying preload. The Ees value is then matched to simultaneous pulmonary arterial (PA) elastance at end systole (Ea), calculated as ESP pressure divided by stroke volume (SV). The ratio of Ees to Ea (Ees/Ea) is termed RV-PA coupling, preservation of which indicates maintenance RV functioning in the face of increasing afterload [1]. However, while the MB method is generally regarded as the reference standard, it requires continuous, accurate measurement of RV volume and is therefore not readily applicable in most clinical settings.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Singh has nothing to disclose.Conflict of interest: Dr. Oakland has nothing to disclose.Conflict of interest: Dr. Elassal has nothing to disclose.Conflict of interest: Dr. Heerdt reports grants from NTT Research, grants from IMPERATiV, other from RVMetrics, LLC, outside the submitted work. ER -